Herbal drugs are safe and show significantly fewer side effects than their synthetic counterparts. Curcumin (an active ingredient primarily found in turmeric) shows therapeutic properties, but its commercial use as a medication is unrealized, because of doubts about its potency. The literature reveals that electrospun nanofibers show simplicity, efficiency, cost, and reproducibility compared to other fabricating techniques. Forcespinning is a new technique that minimizes limitations and provides additional advantages to electrospinning. Polymer-based nanofibers—whose advantages lie in stability, solubility, and drug storage—overcome problems related to drug delivery, like instability and hydrophobicity. Curcumin-loaded polymer nanofibers show potency in healing diabetic wounds in vitro and in vivo. The release profiles, cell viability, and proliferation assays substantiate their efficacy in bone tissue repair and drug delivery against lung, breast, colorectal, squamous, glioma, and endometrial cancer cells. This review mainly discusses how polymer nanofibers interact with curcumin and its medical efficacy.
Highlights
The life-threatening side effects of cancer treatment are addressed using nano-formulations and combinational therapy.
Herbal drugs displayed potency in curing cancer using a nanofiber based device.
Allopathic anti-cancer drugs can be delivered at a targeted site using a nanofiber based drug carrier which improves bioavailability to a great extent.
A combination of an herbal and allopathic anticancer drug could be a possible life-saving union to cure cancer.
One-step wet chemical method has been employed for the synthesis of silver (Ag) nanofluids followed by the preparation of polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA) and PVP–PVA mixed-dispersant-stabilized nanofluids by varying the concentration ratio of dispersants for the viscosity and thermal conductivity analysis. The optical absorption studies indicate the presence of nanoparticles in the prepared fluids (or the formation of the silver nanoparticles). The shape and size of the nanoparticles are confirmed by the field emission scanning electron microscopy, and the particle size distribution and zeta potential analysis were carried out by using dynamic light scattering. It is observed that the thermal conductivity of Ag nanofluids increases with an increase in the dispersant concentration with respect to the temperature. The maximum thermal conductivity enhancement of Ag nanofluids was observed in the presence of an equimolar ratio of PVP–PVA (1:1:1) blends as stabilizers.
Graphic abstract
Biotechnology and food science have pioneered the notion of cultured meat. Conventional meat production face issues related to butchering, dietary inadequacy, foodborne disease, and the emanation of methane, which cultured meat evades while promising the texture and feel of real meat. Mass production techniques for plant-based meat analogs have been developed, whose products have hit the market. In vitro production on scaffolding and self-organizing techniques have manufactured small-scale meat products offering tunable nutrition, although more specialized contrivances are needed to build a cultured meat framework on a large scale. Prospective techniques like 3D/4D bio-printing, biophotonics, and cloning are current research subjects. Cultured meat needs to overcome societal and regulatory hurdles prior to commercialization, and, in any event, is a long-term necessity for humankind, although the high production cost and affirmation among people is the principal impediment.
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