Glomerulus diameter and Bowman's space thickness in renal microscopic images indicate various diseases. Therefore, the detection of the renal corpuscle and related objects is a key step in histopathological evaluation of renal microscopic images. However, the task of automatic glomeruli detection is challenging due to their wide intensity variation, besides the inconsistency in terms of shape and size of the glomeruli in the renal corpuscle. Here, a novel solution is proposed which includes the Particles Analyzer technique based on median filter for morphological image processing to detect the renal corpuscle objects. Afterwards, the glomerulus diameter and Bowman's space thickness are measured. The solution was tested with a dataset of 21 rats' renal corpuscle images acquired using light microscope. The experimental results proved that the proposed solution can detect the renal corpuscle and its objects efficiently. As well as, the proposed solution has the ability to manage any input images assuring its robustness to the deformations of the glomeruli even with the glomerular hypertrophy cases. Also, the results reported significant difference between the control and affected (due to ingested additional daily dose (14.6 mg) of fructose) groups in terms of glomerulus diameter (97.40 ± 19.02 µm and 177.03 ± 54.48 µm, respectively).
The paper highlights the peculiarities of histological changes in different subdivisions of the intralobular duct of the submandibular gland in rats in case of experimental hyperglycemia. Materials and methods. The study included 40 male Wistar rats weighing 230 to 250g. Experimental hyperglycemia was induced by a single intraperitoneal administration of streptozotocin. Biochemical and morphological investigations were conducted; the morphometric analysis was carried out. Results. Since the 28th day of the experiment, on the background of dynamic increase in the levels of glucose and glycated hemoglobin in the blood, there was observed the development of dystrophic changes in epithelial cells of the granular and striated ducts being accompanied by a gradual decrease in epithelial cell height by 10.28 -29.46% and 10.77 -28.28%, respectively. Morphological changes in the intercalated ducts were detected later -since the 42 nd day of the experiment and the decrease in their epithelial cell height -by 15.60%, was seen on the 70 th day only. Conclusions. Morphological changes in different subdivisions of the intralobular duct are of dystrophic nature and can be histologically detected since the 28 th day of the experiment; they depend on the duration of hyperglycemia and are accompanied by a dynamic decrease in epithelial cell height.
This paper presents the possibilities of Mendeley – a reference manager and social network for researchers.The key aspects of using this software as an effective reference manager as well as a tool for organizing full-text archive of publications and processing scientific sources when conducting research are highlighted. The possibilities of Mendeley as a social network, namely a means of communication and collaboration between researchers, sharing of reference database and search for new scientific publications are presented as well.In general, Mendeley, due to its functionality, is an integral part of the scientific research carried out by students, scientists or laboratory research groups. The use of Mendeley by all members of the research project will allow them to effectively search for original sources and analyze them; to quickly create the reference list according to different styles; to follow other researchers in order to view relevant papers; to greatly enhance the quality of the research; to expand the potential readership of their publications.
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