Effect of Hyperglycemia on the Excretory Ducts of the Submandibular Gland (Histologic Study)

Abstract

The paper highlights the peculiarities of histological changes in different subdivisions of the intralobular duct of the submandibular gland in rats in case of experimental hyperglycemia. Materials and methods. The study included 40 male Wistar rats weighing 230 to 250g. Experimental hyperglycemia was induced by a single intraperitoneal administration of streptozotocin. Biochemical and morphological investigations were conducted; the morphometric analysis was carried out. Results. Since the 28th day of the experiment, on the background of dynamic increase in the levels of glucose and glycated hemoglobin in the blood, there was observed the development of dystrophic changes in epithelial cells of the granular and striated ducts being accompanied by a gradual decrease in epithelial cell height by 10.28 -29.46% and 10.77 -28.28%, respectively. Morphological changes in the intercalated ducts were detected later -since the 42 nd day of the experiment and the decrease in their epithelial cell height -by 15.60%, was seen on the 70 th day only. Conclusions. Morphological changes in different subdivisions of the intralobular duct are of dystrophic nature and can be histologically detected since the 28 th day of the experiment; they depend on the duration of hyperglycemia and are accompanied by a dynamic decrease in epithelial cell height.

Histological and Immunohistochemical Analysis of Green Coffee Aqueous Extract Effect on Parotid Salivary Gland in Streptozotocin Induced Diabetic Albino Rats

“…In the present study, flattening of ID cells in diabetic subgroup IIB and SD cells in both diabetic subgroups was detected, this result is in agreement to [26] as epithelial cell height in the ID and SD of diabetic submandibular SG begins to change due to the direct effect of hyperglycemia and oxidative stress and indirect due to diabetic microangiopathy. SD of both diabetic subgroups showed loss of basal striation, this result agrees with [27] and they accredited this due to degeneration of mitochondria which appeared swollen with loss of cristae.…”

Hyperglycemia Induced Apoptosis Changes in Salivary Gland Cells of Mice

“…Sandberg GE et al (1970) have reported that oral dryness symptom of type 2 diabetic patients is significantly higher than that in normal people [6]. In addition, it is reported that a study showing morphological changes in the intralobular duct of the salivary gland due to hyperglycemia has been reported [9]. It was reported that function of salivary glands and salivation decreased due to apoptosis of salivary glands cells caused by head and neck radiation therapy [10] [11].…”