IL-17RB is up-regulated on blood and sputum mDCs and pDCs after allergen inhalation. IL-25 modulates pDC function through an effect on TLR9 expression.
This study was funded by the British Medical Association James Trust Award. I.S. is funded by a fellowship from the European Respiratory Society/European Union Marie Curie Award. Disclosure of potential conflict of interest: I. Satia reports grant from the BMA James Trust Award and the North West Lung Centre Grant; personal fees from Educational Talks for GPs; and sponsorship to attend conference meetings outside the submitted work. P. D. Mitchell reports grants from the Irish Asthma Society and Teva and personal fees from Educational Talks for GPs and specialists outside the submitted work. P. M. O'Byrne reports personal fees from the Oversight Committee for LABA Safety study; consulting fees from AstraZenca, GlaxoSmithKline, Merck, and Boehringer; and grants from AstraZeneca and Genentech outside the submitted work. J. A. Smith reports grants from the British Medical Association James Trust during the conduct of the study and grants and personal fees from Ario Pharma, GlaxoS-mithKline, NeRRe Pharmaceuticals, Menlo, and Bayer; personal fees from Boehringer Ingleheim, Genentech, and Neomed; grants and personal fees from Merck; nonfinancial support from Vitalograph; personal fees from Cheisi; and grants and personal fees from Afferent outside the submitted work. In addition, J. A. Smith has a patent A method for generating output data licensed. The rest of the authors declare that they have no relevant conflicts of interest. Clinical Trial Registration: www.controlled-trials.com ISRCTN79930571.
Disclosure of potential conflict of interest: A. Asarnoj has received travel support from MEDA; serves as a consultant for MEDA; and received payments for lectures from ThermoFisher. C. Lupinek receives payment for lectures from ThermoFisher. J. M. Anto receives grant support from EU FP7 MeDALL. J. Bousquet serves on the advi
AXP1275 50 mg administered daily was safe and well tolerated, and there was no difference in the type, severity or frequency of treatment-emergent adverse events in subjects while receiving AXP1275 compared to placebo. AXP1275 increased the methacholine PC ; however, the low and variable exposure to APX1275 over a short treatment period may have contributed to poor efficacy on other outcomes.
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