Punica granatum (pomegranate), the member of Punicaceae family, is used in the prevention and treatment of health disorders. P. granatum contains diverse range of phytochemicals including ellagic acid, punicalagin, pedunculagin, quercetin, rutin, tannic acid, polyphenol, anthocyanins, and catechins. This review aims at providing an overview of the chemical constituents, antibacterial, anti-inflammatory, and antioxidant properties of P. granatum, and its role in the prevention and treatment of gingival and periodontal diseases.
Purpose: Pomegranates have been shown to possess anti-inflammatory and antioxidant properties. This study aimed to evaluate the effects of Punicalagin (Pomegranate extract) on IL-1β and SOD levels in chronic periodontitis patients.
Materials and Methods: 30 patients were included in the study. The sites were randomly divided into control site and test site. Control sites were treated with Scaling and Root Planing (SRP) alone and test sites were treated with punicalagin gel along with SRP. Clinical parameters such as probing pocket depth, Clinical Attachment Level (CAL), Gingival Index (GI), Plaque index (PI), Sulcus Bleeding Index (SBI) and biochemical markers such as IL-1β and Superoxide Dismutase levels were compared between baseline and at 21 days post therapy.
Results: Test sites showed significant differences when compared to control sites in relation to all clinical and biochemical parameters.
Conclusion: Within the limitations of this study, there is an improvement in the clinical parameters with an increase in the anti-oxidant marker level and a decrease in inflammatory marker level when punicalagin gel was placed along with Scaling and Root Planing in patients with Chronic Periodontitis.
Background and Objectives:The defi ciency of estrogen at menopause is a contributing factor that increases susceptibility to resorption due to periodontal infl ammation. Statins have been used successfully in postmenopausal osteopenia. Simvastatin has antiinfl ammatory and antiresorptive properties. This study assessed subgingivally delivered 1.2 mg simvastatin in situ gel in postmenopausal women with chronic periodontitis. Materials and Methods: A total of 40 bilateral pockets (≥4 mm) in 20 systemically healthy postmenopausal subjects were randomized as site A and B, which received either the simvastatin in situ gel or placebo gel after scaling and root planing. Site-specifi c indices, probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 3 and 6 months. The data were analyzed using descriptive statistics, repeated measure ANOVA, paired and independent samples t-test. Results: A statistically signifi cant (P < 0.05) decrease in PD and improved CAL was observed in both groups over 3 and 6 months. The comparisons of clinical parameters showed statistically signifi cant (P < 0.05) improvements in test sites over the control sites. Conclusion: Simvastatin in situ gel showed improvements in clinical parameters and prolonged anti-infl ammatory eff ects. The results encourage the use of simvastatin in situ gel for the predictable treatment of chronic periodontitis in postmenopausal women.
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