Development of pH Sensitive Microspheres of Esomeprazole Magnesium Using Natural Gums for Zollinger-Ellison Syndrome

Balamuralidhara, V.; Kumar, Tamilselvan; Gupta, Narain; Moin, Afrasim; Gangadharappa, H.V.

doi:10.2174/2210304x11202020108

Cited by 4 publications

(4 citation statements)

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“…pH plays as a vital regulatory role in maintaining the stability and function of cells and organisms. 52,53 Because PFCD displayed an excellent ECL performance among these cyclopentadienols, we regard it as the target ECL emitter for further research. Due to the influence of aromaticity and the conjugated structure, there is a relatively large range for the peak of hydroxyl groups in the NMR spectra (from 2.3 to 5.1 ppm, Figures S1, S3, and S5, Supporting Information), indicating that the hydrogen atom on PFCD possesses a high chemical reactivity.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Aromaticity-Enhanced pH-Responsive Electrochemiluminescence of Cyclopentadienols

Han

Sang

et al. 2022

Anal. Chem.

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Due to significantly tackling the problems of aggregation-caused quenching and water insolubility, aggregationinduced emission electrochemiluminescence (AIE-ECL) has emerged as a research highlight in aqueous detection and sensing. Herein, we reported a series of cyclopentadienols featuring excellent AIE-ECL properties on the basis of an enhanced aromaticity strategy. In detail, substituents profoundly determined ECL emission by affecting the characteristic absorption peak intensity ratio in UV−vis spectra and lowest unoccupied molecular orbital (LUMO)−highest occupied molecular orbital (HOMO) energies. It was found that 1,2,3,4,5-pentafluorophenyl cyclopentadienol (PFCD) containing an electron-withdrawing fluorine substituent, the maximum R/B band ratio, and a smaller LUMO−HOMO band gap demonstrated the best ECL performance. Meanwhile, such an AIE-ECL system displayed a wide response range toward pH (4−12) with a good linear relationship. Our research not only enriched polycyclic aromatic hydrocarbon-based AIE-ECL systems but also established an efficient pH sensor in the aqueous phase.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Aromaticity-Enhanced pH-Responsive Electrochemiluminescence of Cyclopentadienols

Han

Sang

et al. 2022

Anal. Chem.

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“…For example, colon pH varies between 6.4-7.8 while sites of inflammation or cancerous tissue are more acidic ( pH ∼ 5-6). 2,40 To determine the effect of pH on drug release, we performed our experiments using configuration 2 as shown in Fig. 2b, at three different pH values: 5, 7.4, and 9.…”

Section: Effects Of Ph and Ionic Strengthmentioning

confidence: 99%

Electroresponsive nanoparticles for drug delivery on demand

2016

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The potential of electroresponsive conducting polymer nanoparticles to be used as general drug delivery systems that allow electrically pulsed, linearly scalable, and on demand release of incorporated drugs is demonstrated. As examples, facile release from polypyrrole nanoparticles is shown for fluorescein, a highly water-soluble model compound, piroxicam, a lipophilic small molecule drug, and insulin, a large hydrophilic peptide hormone. The drug loading is about 13 wt% and release is accomplished in a few seconds by applying a weak constant current or voltage. To identify the parameters that should be finely tuned to tailor the carrier system for the release of the therapeutic molecule of interest, a systematic study of the factors that affect drug delivery is performed, using fluorescein as a model compound. The parameters studied include current, time, voltage, pH, temperature, particle concentration, and ionic strength. Results indicate that there are several degrees of freedom that can be optimized for efficient drug delivery. The ability to modulate linearly drug release from conducting polymers with the applied stimulus can be utilized to design programmable and minimally invasive drug delivery devices.

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“…(2) Pharmaceutical science: in the single-scan automatic determination of the releasing pH in pH-sensitive drug carriers for cancer therapy. 21 (3) Biochemistry: in automatic studies on pH-sensitive folding/ unfolding of proteins 22 and DNA. 23 (4) Supramolecular science: in automatic studies of switching/ unswitching of pH-sensitive assembling, 24 sol-gel transition, 25 etc.…”

Section: Discussionmentioning

confidence: 99%

[1.1.1]Cryptand: directions for its use as a variable-pH kinetic molecular device

et al. 2014

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Development of pH Sensitive Microspheres of Esomeprazole Magnesium Using Natural Gums for Zollinger-Ellison Syndrome

Cited by 4 publications

References 0 publications

Aromaticity-Enhanced pH-Responsive Electrochemiluminescence of Cyclopentadienols

Aromaticity-Enhanced pH-Responsive Electrochemiluminescence of Cyclopentadienols

Electroresponsive nanoparticles for drug delivery on demand

[1.1.1]Cryptand: directions for its use as a variable-pH kinetic molecular device

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