Background: Heart failure continues to be a major challenge to healthcare; several resting and exercise electrocardiographic parameters have been investigated to predict the left ventricular diastolic dysfunction (LVDD). Objectives: We aimed to study different parameters in resting and exercise stress test to evaluate whether they can predict left ventricular diastolic dysfunction (LVDD). Methods: One hundred and forty patients, classified into 2 groups according to LVDD, were assessed by measurement of normal and corrected QT interval, T wave peak to T wave End and P wave dispersion in resting ECG. Exercise stress test looking for hump sign (upward deflection of the ST-segment) was done. The relationships between these ECG parameters and LVDD were investigated. Results: We found significant occurrence of hump sign in patients with LVDD, and there was a significant difference between both groups regarding QTc and P wave dispersion. P wave dispersion was significantly higher in patients with LVDD. Sensitivity and specificity of the ST hump sign in prediction of LVDD were 86% and 78% respectively. We also concluded that P wave dispersion at cutoff value about 0.045 ms had the highest sensitivity (sensitivity 98%, specificity 64%) while QTc at cutoff value 0.395 ms had the highest specificity (sensitivity 81%, specificity 79%). Conclusion: P wave dispersion and hump sign were the most sensitive ECG signs for the prediction of LVDD. ª 2015 Production and hosting by Elsevier B.V. on behalf of Egyptian Society of Cardiology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

There was a comparable and significant improvement in QoL post-ablation in patients who underwent ablation using PVAC catheter and conventional techniques.

Essential hypertension is an important risk factor for target organ damage. The brain is among the target organs infrequently visited. The authors evaluated whether an abnormal Mini‐Mental Score Examination (MMSE) score predicts uncontrolled hypertension even if office blood pressure is normal. Seventy‐seven hypertensive patients were included. The cognitive function of each patient was assessed using MMSE and a customized brain magnetic resonance imaging study. Patients were classified into normal cognitive function group and mild, moderate, and severe cognitive impairment groups. A significance level of P=.05 was used. There was a higher percentage of uncontrolled BP in every cognitive impairment class. In patients older than 65 years, MMSE score had a sensitivity and specificity of 94% and 83%, respectively, in the prediction of uncontrolled hypertension. MMSE is a simple test to run in the clinic to predict whether patients have well‐controlled blood pressure.

Objectives: To study the ambulatory measured blood pressure (ABPM) profile in normotensive patients with mild cognitive impairment (MCI). Patients and Methods: The study was designed as a case control study including 50male patients with mild cognitive impairment in the age group of 30-50 years old. The control group included 30 volunteers with no cognitive impairment and in the same age group (30-50 years old) and same gender. Mini-mental estate examination, office and ABP monitoring (ABPM) and brain MRI scans were done for cases and controls. Results: Thirty patients (60%) with MCI revealed a non-dipper blood pressure pattern. Sleeping systolic blood pressure and sleeping systolic load were significantly higher in patients with MCI than in normal volunteers (p = 0.01). MRI brain showed more white matter lesions (WMLs) in patients with MCI than in normal volunteers; however, this didn't reach significance level (p = 0.056). Conclusion: MCI in normotensive young adult patients could reflect an abnormal circadian blood pressure rhythm. Ambulatory blood pressure monitoring could be an essential investigation in young adult MCI patients.

Objective The aim of the study was to assess the potential of follicle-stimulating hormone receptor (FSHR) gene polymorphism for predicting ovarian response to FSH stimulation.Methods We retrospectively analyzed clinical data of 150 infertile women younger than 40 years who were attending the National Research Center infertility clinic, Egypt. These women were divided into two groups: group I patients (75 patients) were considered as poor ovarian responders according to the 'Bologna criteria' and group II patients (75 patients) were considered as good responders. Analysis of FSHR gene polymorphism at position 680 was carried out after the women were genotyped.Results Among Egyptian women, the frequency of the Asn/Asn genotype was significantly more prevalent in the poor responder group (65.3%) compared with the good responder group (24.0%) (P < 0.05); the Ser/Asn genotype was seen in 34.7% of poor responders compared with 64% of good responders and the Ser/Ser phenotype was seen only in good responders (12%).