Histopathological alterations in the liver of intermediated hosts infected with Echinococcus granulosus parasite can be occurred by necrotic expansion as a result of an increase in growth of the parasite larva stage (metacestode), which may cause perturbation in production of liver function markers. Thus, this study aims to determinate the liver biochemical profile and some serum electrolytes of E. granulosus-infected sheep at different hydatid cyst infection ratios (IRs). fifty livers from naturally E. granulosusinfected sheep with five livers from uninfected-sheep as a control group were enrolled in this study. Cardiac blood samples under sterilized conditions were gently collected and isolated sera were biochemically assayed for determination of liver function markers including; Aspartate transaminase (AST), Alanine transaminase (ALT), alkaline phosphatase (ALP), Albumin (ALB) and total protein (TP), as well as the level of some serum electrolytes including Ca, K, Na and Cl using fully automatic biochemical analyzer, FUJI-Film. The current data indicated a progressive increase in the level of AST, ALT, ALP, Ca and K. The level of ALB and TP were gradually declined with a rise of liver infection ratio with hydatid cysts. In conclusion, the current findings indicated perturbation of liver function markers and the level of some serum electrolytes, mainly Ca and K in E. granulosus-infected sheep based on the infection ratio of liver. Additionally, acute and chronic infection of E. granulosus parasites in sheep can be determined based on the level of liver function markers in serum.
This study was conducted to elucidate the effect of different concentrations of zinc element on male fertility of swiss albino mice by using atomic absorption, and determination of acid phosphatase activity (Ec.3.1.3.2) compared with control groups. The mice were divided into three groups (10 mice / group) and they were three months old. The first group was treated with 0.5 mg / kg body weight and the second group with 1.5 mg / kg body weight with zinc, while the third group considered as control group. The mice treatment was for 15 and 30 days for the two experiment groups. The results showed a significant increase (p≤0.05) in weight of testes in the group which treated by concentration 1.5 mg / kg b.w compared with control group. Significant increase (p≤0.05) was also found in testes weight when using the high concentration of zinc compared with the low concentration. Results also showed a significant increase in sperm count of groups treated with zinc as compared with control group. Significant increase (p≤o.o5) in sperm motility was detected in both the first and second groups as compared with control. Significant decrease (p≤0.05) in slugish sperm in group with high concentration of zinc as compared with control. Significant increase in both groups in acid phosphatase activity and the concentration of fructose treated with concentrations 0.5 and 1.5 mg / kg b.w as compared with control.
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