Importance:The global infection outbreak by the new SARS-CoV-2 prompted community containment schedules; however, social isolation is a predictor of psychological distress.Objective: To determine whether social isolation, in Brazil, led to higher signs of psychological distress, and which intra-and inter-psychic variables mediated this effect. The following hypotheses were tested: 1) in isolated individuals, loneliness activates distancing
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