OBJECTIVE: To determine the frequency of most common bacterial organisms in nosocomial blood stream infections STUDY DESIGN: A Cross-sectional descriptive study PLACE AND DURATION: In Department of Paediatric Medicine, Fauji Foundation Hospital, Rawalpindi, Tertiary care hospital over a period of 06 months from 6th July 2017 to 6th Jan 2018 METHODOLOGY: Total 385 patients admitted in PICU were included in the study according to the inclusion criteria. Patients were monitored from the time of admission to their final outcome for development of hospital acquired infections, based on standard definitions. Blood sample for culture were collected aseptically according to the protocol of the microbiology laboratory. The bottles were incubated for 7 days. Patients were monitored from time of the blood culture yielding growth until culture report becomes available. Data was calculated through a structured Performa confidentiality of patient was maintained. RESULTS: Pseduomonas Aeruginosa and Salmonellia Tpyhi were the most common bacterial organism 83 (21.6) in nosocomial blood stream infection whereas E.Coli and Klebsiella found in 77 (20.0) and 67 (17.4) patients respectively. CONCLUSION: The study concluded that the frequency of most common bacterial organisms in nosocomial blood stream infections is substantial. Thus, early initiation of appropriate antibiotic therapy help in contributing significantly towards decrease in mortality rates due to blood stream infections. KEYWORDS: Nosocomial, Bloodstream infection, Intensive care unit
People all around the world suffer from liver diseases, which is a serious health problem. Purpose: To observe the synergistic effects of Silymarin and Cymbopogoncitratus stem infusion on liver in acetaminophen induced hepatotoxicity in rats. Study Design: Laboratory-Based Randomized Control Trial. Methodology: Total forty adult rats were divided into four groups (10 each). Group 1 was taken as control group. After initial sampling at day 0, Acetaminophen (300 mg/kg) was injected to 30 rats via intra-peritoneal route. At day 8, rats were further divided into three groups. Group 2 was a disease control group. Group 3 was given Silymarin (100 mg/kg) and group 4 was treated with Silymarin (100 mg/kg) plus Cymbopogoncitratus stem infusion (130 mg/kg) through gavage method for fourteen days. At day 21, rats were sacrificed for histological examination after terminal sampling. Statistical Analysis: Mean± SEM was calculated and analyzed through SPSS 20. P-value less than 0.05 was considered statistically significant. Results: Rats from group 2 showed marked elevation (p<0.05) in serum markers. There was marked sinusoidal dilatation and necrosis present in group 2 rats.Silymarinin group 3 and Silymarin plus Cymbopogoncitratus stem infusion in group 4 significantly lowered the biochemical enzymes as well as considerably reversed the histological changes in comparison to group 2 rats. Conclusion: We concluded in present study that synergism was observed in group 4 rats. There was more reversal of hepatic injury in group 4 rats. Key words: Cymbopogoncitratus, Silymarin and Synergism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.