SummaryBackground: Patients with hypertrophic cardiomyopathy (HCM) associated with a deletion of lysine 183 (K183del) in the cardiac troponin I (cTnI) gene suffer sudden cardiac death at all ages. However, the correlation between QT variables and sudden cardiac death in these patients remains uncertain.Hypothesis: We evaluated the correlation between QT variables and sudden cardiac death and/or ventricular tachyarrhythmia (SCD/VT) in patients with HCM associated with the cTnI mutation.Methods: We analyzed 10 probands with HCM associated with the cTnI gene K183del and their family members. The subjects were divided into three groups: Group A (n = 7), mutation carriers with SCD/VT; Group B (n = 16), mutation carriers without SCD/VT; Group C (n = 24), no mutation carriers. QT intervals were corrected using Bazett's formula.Results: Maximum QTc and corrected QT dispersion were significantly longer in Groups A and B than in Group C. However, there were no differences in either parameter be-
Aim: An evaluation of the relation between small dense low-density lipoprotein cholesterol (sd-LDL-C) levels measured by the heparin-magnesium precipitation method and metabolic syndrome (MetS).
The clinical efficacy of glucagon-like peptide-1 (GLP-1) analogs in patients with acute myocardial infarction (AMI) is uncertain. The purpose of the present study was to evaluate the effects of the GLP-1 analog liraglutide on left ventricular (LV) remodeling in patients with AMI. We retrospectively evaluated the effects of liraglutide on LV remodeling assessed by cardiac magnetic resonance imaging (CMRI) in 15 patients with type 2 diabetes who were successfully treated with primary percutaneous coronary intervention (PCI) for AMI. Patients were divided into two groups based on their hypoglycemic medication: liraglutide use (group L; n = 6) or standard therapy (group S; n = 9). The CMRI findings in the early phase and at the 6-month follow-up were compared. At the 6-month follow-up, group S showed increases in LV end-diastolic (from 64 to 74 mL/m(2), p = 0.08) and end-systolic (from 38 to 45 mL/m(2), p = 0.13) volume indexes, whereas no such increase was observed in group L. The LV mass index (LVMI) was significantly smaller in group L than in group S at baseline (64 vs. 75 g/m(2), p = 0.05) and at follow-up (56 vs. 78 g/m(2), p = 0.009). Multivariate regression analysis showed that liraglutide use was an independent negative predictor of LVMI (β = -0.720, p = 0.003). In conclusion, liraglutide may be able to prevent the progression of LV remodeling and is associated with a lower LV mass in diabetic patients with AMI undergoing primary PCI.
he incidence of cardiac metastases at autopsy ranges from 1.5% to 20.6% (mean 6%) in patients with malignant diseases. [1][2][3] Carcinomas of the lung and breast, malignant melanoma, lymphomas, and leukemias rank among the most common tumors associated with this condition. 4,5 Modes of spread to the heart include direct invasion, hematogenous spread, and lymphogenous metastasis. The most common site of cardiac involvement is the pericardium with frequencies ranging from 62% to 81%, 6 whereas myocardial or endocardial involvement is rare.For cervical carcinoma, the most common sites of extrapelvic metastasis are the lung, bone, or the cervical or supraclavicular lymph nodes. 7 Cardiac metastasis is very rare with a frequency ranging from 1.6% to 8.0%. 8 We report a case of right ventricular (RV) metastasis from a primary cervical carcinoma.
Case ReportA 49-year-old female presented with a 1-month history of cough and low-grade fever. Vital signs at the time of presentation were height of 151 cm, weight of 44 kg, temperature of 37.4°C, heart rate of 120 beats/min, and blood pressure 120/82 mmHg. Jugular venous distension was not evident, nor were superficial lymph nodes palpable. A systolic ejection murmur was noted at the second intercostal space near the left sternal border. An abnormal mass, which was the size of a hen's egg, was palpable in the right lower quadrant just below the umbilicus. No edema was noted. Chest X-ray demonstrated mild cardiac enlargement without pleural effusion or abnormal lung shadows. Electrocardiography (ECG) revealed sinus tachycardia, inverted T waves in leads V1 to V4, and low voltage in the limb leads. A 49-year-old female presented with a 1-month history of cough and low-grade fever. Echocardiography showed a large mass in the right ventricle and percutaneous right ventricular endomyocardial biopsy provided the histologic diagnosis. Despite radiotherapy and chemotherapy, the patient died. At autopsy, the metastatic deposit in the heart was larger than the primary cervical carcinoma. (Jpn Circ J 2001; 65: 761 -763)
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