ChemInform Abstract The diphosphines (I) are employed as ligands in the asymmetric hydrogenation of the α-amino ketones (II) to give selectively the (S)-configurated amino alcohols (III). (IIIb) reacts with potassium thiocyanate (IV), producing the optically active iminothiazolidine (V) which is a precursor of (S)-levamisole (VI).
The chiral diphosphines (2S,4S)‐(I), derived from proline, are employed as ligands in the asymmetric hydrogenation of the amino ketone (II), yielding the (S)‐phenylephrine (S)‐(III).
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