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Camurati-Engelmann disease (CED, MIM 131300) is an autosomal dominant, progressive diaphyseal dysplasia characterized by hyperosteosis and sclerosis of the diaphyses of long bones. We recently assigned the CED locus to an interval between D19S422 and D19S606 at chromosome 19q13.1-q13.3, which two other groups confirmed. As the human transforming growth factor-1 gene (TGFB1) is located within this interval, we considered it a candidate gene for CED.

Spherical mesoporous silica was prepared by dispersing tetrabutoxysilane (TBOS) in an alkaline solution into which a cationic surfactant had been dissolved. The spherical mesoporous silica was prepared within the limited concentration regions of the surfactant. The diameter of the spherical mesoporous silica was about 500 mm, and the BET specific surface area was above 1000 m 2 g À1 . Within the as-synthesized spherical mesoporous silica, phenol and some organic compounds in aqueous phase were solubilized into the hydrophobic free space consisting of the hydrocarbon group of surfactants. The extent of solubilization was correlated with equilibrium concentration in aqueous phase by a Langmuir-type equation. The maximum solubilization for phenol was proportional to the BET specific surface area of the calcined spherical mesoporous silica. For some organic compounds maximum solubilization was directly proportional to a hydrophobic index ofthe organic compound, log (P OW ), where P OW is the distribution coefficient between the octanol and water phases.

High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks. Systolic blood pressure and urine volume were increased in WBKDF-HS and Wistar-HS. Body weight gain and food consumption were comparable between NS and HS in both strains. Plasma and urine glucose levels were significantly increased in WBKDF-NS but not in WBKDF-HS. HOMA-IR in WBKDF-HS was significantly lower compared with that in WBKDF-NS. The high plasma adiponectin level in WBKDF-NS compared with that in Wistar-NS was further enhanced in WBKDF-HS. Glycogen deposits and fat droplets in the livers of WBKDF-HS were reduced compared with those of WBKDF-NS. The present study demonstrated that HS intake ameliorated hyperglycemia and insulin resistance in WBKDF rats, which may be due to increased plasma levels of adiponectin.

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