Three novel triterpenoid saponins, dianosides G, H and I, together with the known saponin, azukisaponin IV, have been isolated from DIANTHUS SUPERBUS var. LONGICALYCINUS. The structures of the new saponins have been assigned as indicated in formulas 1,2 and 3, respectively, by spectral and chemical evidence.
Novel triterpenoid saponins, dianosides A and B, showing analgesic activity, have been isolated from DIANTHUS SUPERBUS var. LONGICALYCINUS herbs. Degradative and spectroscopic studies have established their structures as shown in formulas 1 and 2.
The triterpenoid saponins isolated from the herbs of Dianthus superbus var. Iongicalycinus have been evaluated for analgesic and antihepatotoxic activities. The saponins of the gypsogenic acid series were more intensely analgesic than those of the dianic acid series. The efficacy of substances in the former series was potentiated by increased hydrophilic character. On the other hand, the aglycones elicited antihepatotoxic activity in a CCI4-induced cytotoxicity assay, and this activity decreased as the number of hydroxyl groups increased. However, they mediated no appreciable antihepatotoxic activity m a GaIN-induced cytotoxicity assay. This was probably due to concomitant cytotoxic activity caused by the substances themselves. No definite structure-activity relationship was found in the antihepatotoxic actions of the saponins.
On the basis of chemical and spectroscopic evidence, the structures of four triterpenoid saponins, dianosides C, D, E and F, from DIANTHUS SUPERBUS var. LONGICALYCINUS herb, have been elucidated as shown in formulas 1, 2, 3 and 4, respectively.
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