HUMAN HEPATIC CYTOCHROME P450 (CYP) AND GENETIC POLYMORPHISM IN DRUG METABOLISMMany drugs undergo a hepatic biotransformation, an essential function that enhances their hydrophilicity and thus facilitates their removal from the human body. The oxidative metabolism of drugs in the liver Aliment

No abstract

The results of the genotyping test for CYP2C19 seem to predict cure of H. pylori infection and peptic ulcer in patients who receive dual therapy with omeprazole and amoxicillin.

The majority of patients without initial eradication of H pylori had an extensive metabolizer CYP2C19 genotype but were successfully re-treated with high doses of lansoprazole and an antibiotic to which H pylori was sensitive, such as amoxicillin, even when the patients were infected with clarithromycin-resistant strains of H pylori.