Heart valve flow computation requires accurate representation of boundary layers near moving solid surfaces, including the valve leaflet surfaces, even when the leaflets come into contact. It also requires dealing with a high level of geometric complexity. We address these computational challenges with a space-time (ST) method developed by integrating three special ST methods in the framework of the ST Variational Multiscale (ST-VMS) method. The special methods are the ST Slip Interface (ST-SI) and ST Topology Change (ST-TC) methods and ST Isogeometric Analysis (ST-IGA). The computations are for
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