The level exchanging buffer of large erecting hydraulic cylinder is one of the core issues in the process of rapid erecting equipment development. This paper combines the actual, building analysis platform of fluid-structure interaction by using fluent and workbench,researching the effect of the change of flow field and fluid-structure interaction on the structure of buffer throttling when the throttle device in different buffer position. The results show that the hydraulic cylinder buffer zones have obvious pressure gradient.The effect of fluid-structure interaction reflected in the pressure gradient of cylindrical flow field lead to the overall strain values of buffer device coupling surface produce gradient change.
Accessible chromatin refers to the active regions of a chromosome that are bound by many transcription factors (TFs). Changes in chromatin accessibility play a critical role in tumorigenesis. With the emergence of novel methods like Assay for Transposase-accessible Chromatin Sequencing, a sequencing method that maps chromatin-accessible regions (CARs) and enables the computational analysis of TF binding at chromatin-accessible sites, the regulatory landscape in cancer can be dissected. Herein, we developed a comprehensive cancer chromatin accessibility database named CATA, which aims to provide available resources of cancer CARs and to annotate their potential roles in the regulation of genes in a cancer type-specific manner. In this version, CATA stores 2 991 163 CARs from 23 cancer types, binding information of 1398 TFs within the CARs, and provides multiple annotations about these regions, including common single nucleotide polymorphisms (SNPs), risk SNPs, copy number variation, somatic mutations, motif changes, expression quantitative trait loci, methylation and CRISPR/Cas9 target loci. Moreover, CATA supports cancer survival analysis of the CAR-associated genes and provides detailed clinical information of the tumor samples. Database URL: CATA is available at http://www.xiejjlab.bio/cata/.
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