A modified Dakin-West one-pot, four-component condensation of an aryl aldehyde, aryl ketone, acetyl chloride and acetonitrile in the presence of silica supported perchloric acid as an active, inexpensive, recoverable and recyclable catalyst is reported for the synthesis of β-acetamido ketones under mechanical stirring and ultrasonic irradiation conditions. This system has advantages of short reaction times, good to excellent yields and the ability to carry out the large scale reactions. The use of ultrasound increases the rate of reactions compared with reactions at reflux conditions.
Silica supported tungstosilicic acid has been used as an effective catalyst for a modified Dakin-West one-pot, fourcomponent condensation of an aryl aldehyde, an aryl ketone, acetyl chloride and acetonitrile for the synthesis of β-acetamido ketones. This catalytic system can act as an active, inexpensive, recoverable and recyclable catalyst. Some advantages of this system are short reaction times, good to excellent yields, easy work up and the ability to be carried out at the large scale reactions.
Synthesis of β-Acetamido Ketones. -A modified Dakin-West condensation is promoted by silica-supported perchloric acid as an inexpensive and recyclable catalyst. Aliphatic aldehydes react under these conditions, but give only poor yields. Interestingly, no acetylation of the phenolic hydroxyl group is observed in the case of (IVf). Ultrasound accelerates the reaction significantly.-(NASR-ESFAHANI*, M.; MONTAZEROZOHORI, M.; GHOLAMPOUR, T.; Chin. J. Chem. 29 (2011)
Silica Supported Tungstosilicic Acid as an Efficient and Reusable Catalyst for the One-Pot Synthesis of β-Acetamido Ketones (IV) via a Four-Component Condensation Reaction-[30 examples]. -(NASR-ESFAHANI*, M.; MONTAZEROZOHORI, M.; GHOLAMPOUR, T.; Bull. Korean Chem. Soc. 31 (2010) 12, 3653-3657, http://dx.doi.org/10.5012/bkcs.2010.31.12.3653 ; Dep. Chem., Yasouj Univ., Yasouj 75918, Iran; Eng.) -R. Langenstrassen 16-069
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