Diverse applications of azo dyes in textiles, paper, leather, cosmetics, pharmaceutical, and food industries along with their deleterious impacts on human beings and aquatic life have raised urgent calls for the treatment of effluent containing azo dyes to remove them or convert them into useful and safe products. This inspires us to modulate acid red 37 to acid red Schiff bases (ARSBs), which were further palladinated to yield monopalladated products (Pd(II)-ARSBs) with an emphasis to obtain new pharmacological (antibiotic and anticancer) candidates. These new cyclopalladated complexes were structurally characterized and pharmacologically evaluated as well for their in vitro antimicrobial, against a common panel of pathogenic G þ and G À bacterial and fungal strains, and anticancer activities against human breast carcinoma (MCF-7) cell lines.

In view of the broad physiological activity of organometallic and organophosphorus compounds, the present paper deals with the synthesis of 2-(4-methoxybenzylidene amino) benzene-thiol, its metallation with mercury (II), nickel (II), palladium (II), and phosphorylation. The antimicrobial activities of all products were investigated. The palladated product displays a significant anticancer activity against human breast carcinoma cell. All the new products were investigated and their structures were elucidated using elemental analyses, thermal analysis, and spectroscopic data.

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Isatin reacts with N-(2-aminoethyl)-1,3-propanediamine in a 1:1 molar ratio in ethyl alcohol to give new Schiff base, 4-[2-(2-oxoindolin-3-ylideneamino)ethylamino.-3,4-dihydro-2H-pyrido[3,2-b]indole. When the reaction is carried out by fusion, two new Schiff bases, 3-(vinylimino)indolin-2-one and 3-(allylimino)indolin-2-one, are obtained with the liberation of ammonia gas. The synthesis, characterization, and the reactivity of the Schiff bases with mercury(II) acetate and palladium(II) chloride are studied. Elucidation of the structures are based on elemental analyses and infrared (IR), ultraviolet (UV), 1 H-nuclear magnetic resonance (NMR), and mass spectroscopic (MS) spectra.