Friendly Synthesis, Metallation, and Phosphorylation of Schiff Base as a Potential Pharmacological Interest

Abstract

In view of the broad physiological activity of organometallic and organophosphorus compounds, the present paper deals with the synthesis of 2-(4-methoxybenzylidene amino) benzene-thiol, its metallation with mercury (II), nickel (II), palladium (II), and phosphorylation. The antimicrobial activities of all products were investigated. The palladated product displays a significant anticancer activity against human breast carcinoma cell. All the new products were investigated and their structures were elucidated using elemental analyses, thermal analysis, and spectroscopic data.

Novel Organometallic Compounds Via Metallation of Some New Schiff Bases

“…[1] New Schiff bases synthesized by More et al [2] from substituted 2-aminothiazole and substituted salicylaldehydes or 2-hydroxy-1-naphthaldehyde were found to exhibit antibacterial and antifungal activities. El-Sawi et al [3] described the reaction of isatin with 1,3-propanediamine giving rise to two pairs of isomeric new Schiff bases, where each of isomers differs from the other according to the mode of addition. El-Sawi et al [4] reported that metallation of some dyes such as direct orange-26 gave new metallated compounds via substitution reaction, C-N bond cleavage, and desulfonation reaction.…”