ABSTRACT.Purpose: To study the association between topographical variation of choroidal thickness and myopic features in healthy eyes, using spectral domain optical coherence tomography (OCT). Methods: Choroidal thickness was measured at the foveal centre (CTF) and 1.5 mm superiorly (CTS), inferiorly (CTI), nasally (CTN) and temporally (CTT) from the foveal centre, using enhanced depth imaging OCT. The temporal width of b zone of peripapillary atrophy (bPPA) was measured on infrared fundus images. The ratio of bPPA width to vertical disc diameter (PVDR) was calculated to correct retinal magnification. Results: This study includes 85 eyes from 85 subjects who had a mean age of 53.9 AE 12.9 years, a mean axial length of 23.56 AE 0.82 mm, a mean refractive error of À0.14 AE 1.80 D, a mean bPPA width of 218.6 AE 181.3 lm and a mean PVDR of 0.13 AE 0.11. The CTF was thickest (266.4 AE 81.6), followed by CTS (256.2 AE 82.5 lm), CTT (251.7 AE 68.4 lm), CTI (247.7 AE 90.3 lm) and CTN (211.0 AE 76.5 lm). There were 31 eyes (36.5%) with CTT thicker than CTF. The CTT/CTF negatively correlated with refractive error (p = 0.012) and positively correlated with axial length (p = 0.031), bPPA width (p = 0.003) and PVDR (p = 0.006). Conclusions: There was a correlation between a thickened choroid, temporal to the foveal centre, with the severity of myopic components in normal eyes. Topographical changes might be induced by stretching of the choroid and sclera towards a temporal direction with eyeball elongation.
We compared the changes in corneal endothelial cells and surgical outcomes after Ahmed glaucoma valve (AGV) implantation with the valve tip inserted either into ciliary sulcus (CS) or anterior chamber (AC). We retrospectively reviewed the medical records of patients treated with CS AGV (n = 24) and AC AGV (n = 38). We compared the preoperative and postoperative central corneal endothelial cell density (ECD), endothelial cell coefficient of variation (CV), best-corrected visual acuity, intraocular pressure (IOP), number of glaucoma medications, and postoperative complications in the two groups. Both groups had similar baseline characteristics and follow-up period. At the last follow-up, the AC AGV group had significantly higher mean monthly ECD loss (17.47 ± 11.50 cells/mm2 vs. 6.40 ± 7.69 cells/mm2, p < 0.0001) and greater proportion of mean monthly ECD loss than the CS AGV group (0.84 ± 0.53 vs. 0.36 ± 0.39%, p < 0.0001). Both groups had similar mean monthly CV changes. The qualified success rates at 2 years were 83.3% and 76.3% for the CS AGV and AC AGV groups, respectively. Although similar surgical outcomes including visual acuity, IOP, number of glaucoma medications, and postoperative complications were obtained following CS AGV and AC AGV, corneal ECD loss was higher in the AC AGV group. Thus, CS AGV may be a better surgical option than AC AGV.
The intraocular lens power prediction accuracy was lower in the CAT and CCT groups than in the OC group. The prediction error was greater in the CAT group than in the OC group, and the direction of the prediction error tended to be towards myopia in the CCT group. The SRK II formula may be more accurate in predicting residual refractive error in the CAT and CCT groups.
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