Mental disorders include a group of diseases that range from depression, schizophrenia, bipolar disorder psychosis, to autism. Various social, cultural, economic, political, and environmental factors can cause mental disorders. In particular, health burden and medical cost for mental disorders including Alzheimer disease (AD), Parkinson disease (PD), and Huntington disease (HD) surged by unforeseen stress, lack of early diagnostic tools for molecular genetics, food safety, and exposure to environmental hazards like pollution (WHO, 2019). Huntington's disease is an autosomal dominant inherited and fatal neurodegenerative disorder caused by the expansion of polyglutamine (known as polyQ) of the huntingtin protein as mutant form which resulted from CAG trinucleotide repeat at N-terminal sequence
We investigated the free radical scavenging and digestive enzyme inhibitory
activities of the hot water extract of peach twig (Prunus
persica L. Bastch). This extract of the peach twigs was further
split up into n-hexane, ethyl acetate (EtOAc), and n-butyl
alcohol(n-BuOH), which resulted in three solvent-soluble
fractions. Free radical scavenging activity was evaluated using
2,2-diphenyl-1-picrylhydrazyl (DPPH) and
2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)
(ABTS+) assay systems, while hypoglycemic effect of the
peach twig extract and the solvent-soluble fractions were tested using
α-glucosidase and α-amylase
inhibition assays. Accordingly, the EtOAc layer showed a greater free radical
scavenging activity compared to other solvent-soluble fractions. Furthermore,
based on the α-glucosidase and
α-amylase assays, the IC50 values were
determined to be 38.2±1.6 and 69.6±6.1
μg/mL for the EtOAc-soluble fractions, respectively.
Taken together, these results suggest that the fractions obtained from the peach
twig extract can be considered as a potential source of natural antioxidant and
hypoglycaemic constituents.
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