PREPIC {published data only} Decousus H. Eight-year follow-up of a randomized trial investigating vena cava filters in the prevention of PE in patients presenting a proximal DVT: The PREPIC trial.

No abstract

No abstract

CD4 þ and CD8 þ memory T cells are identified into central and effector memory subsets, which are characterized by distinct homing patterns and functions. In this investigation, we show that naïve and central memory CD4 þ and CD8 þ T cells are sensitive to hydrogen peroxide (H 2 O 2 )-induced apoptosis, whereas effector memory CD4 þ and CD8 þ T cells are relatively resistant to H 2 O 2 -induced apoptosis. Apoptosis in naïve and central memory CD4 þ and CD8 þ is associated with the release of cytochrome c and activation of caspase-9 and caspase-3, upregulation of Bax and voltage-dependent anion channel (VDAC) expression, and decreased intracellular glutathione (GSH). In vitro GSH and a superoxide dismutase mimetic Mn(III) tetrakis (1-methyl-4-pyridyl) porphyrin inhibited H 2 O 2 -induced apoptosis in both naïve and central memory CD4 þ and CD8 þ T cells. Furthermore, VDAC inhibitor 4,4 0 -diisothiocynostilbene-2,2 0 -disulfonic acid blocked H 2 O 2 -induced apoptosis. These data demonstrate that H 2 O 2 induces apoptosis preferentially in human naïve and central memory CD4 þ and CD8 þ T cells via the mitochondrial pathway by regulating intracellular GSH and the expression of Bax and VDAC.

No abstract