The role of natural idiotypic (Id-Abs) and anti-idiotypic (AId-Abs) autoantibodies against neuroantigens observed in different neurological disorders is not fully understood. In particular, limited experimental evidence has been provided concerning the qualitative and quantitative serological response after acute injuries of the central nervous system or during chronic mental diseases. In this study, we analyzed the specific Id-Abs and AId-Abs serological reactivities against 4 neuro-antigens in a large population of patients with ischemic stroke, schizophrenia, as well as healthy individuals.Patients with ischemic stroke were tested at different time points following the acute stroke episode and a correlation was attempted between autoantibodies response and different patterns of functional recovery. Results showed variable and detectable Id-Abs and AId-Abs in different proportions of all three populations of subjects. Among patients with different functional recovery after ischemic stroke, a difference in time-related trends of Id-Abs and AId-Abs was encountered. Our observations suggest that changes in the production of natural neurotropic Abs may engender a positive homeostatic, beside a possible pathogenic effect, in specific neurological disorders.
BackgroundIn Yakutia, the morbidity and mortality from stroke increased in the past 2 decades. Stroke share in the total mortality structure increased significantly. According to the autopsies, haemorrhagic stroke (HS) was more common in indigenous patients.ObjectiveThe aim of the study was to examine ethnic features of stroke patients of indigenous and non-indigenous ethnicity admitted to Regional Vascular Center (RVC), Yakutsk.DesignThe study used data from a hospital stroke registry, which took into account the cases of acute stroke in 2011. Stroke type and aetiology were determined by clinical examination, computed tomography and magnetic resonance imaging studies, cerebral angiography and ultrasound of cerebral vessels.ResultsA total of 1,108 patients were hospitalized (51.4% male, n=569) in 2011. The mean age was 60.5±12.9 years, male: 59.1±12.8, female: 61.9±13.05. Five hundred and ninety-two ischemic strokes (IS; 53.4%), 236 HS (21.3%), 280 transient ischemic attacks (TIA; 25.3%) were diagnosed. Patients who had a stroke were divided into 3 groups according to their ethnicity: native (n=411; 49.6%), Russians (n=347; 41.9%) and other nationalities (n=70; 8.5%). When comparing the incidence of HS in different ethnic groups, it was found that indigenous patients had more cases of HS than Russians (38% vs. 20.2%, p<0.05; adjusted odds ratio=2.42; 95% confidence interval: 1.72–3.41). Mean age of IS and HS indigenous patients had no significant differences compared with the average age of Russian ethnicity patients (p=0.69; p=0.201, respectively).ConclusionsThe data from this study suggest that among the patients who suffered from stroke in the indigenous population, the share of a haemorrhagic form washigher than those of non-indigenous Caucasians. At the same time, the average age of patients, both having IS and HS had no significant differences by ethnicity. Further studies are needed to establish the causes of ethnic differences of stroke in Yakutia.
государственный медицинский университет имени проф. В. Ф. Войно-Ясенецкого Министерства здравоохранения РФ, ректор-д. м. н., проф. И. П. Артюхов; кафедра медицинской генетики и клинической нейрофизиологии ИПО, зав.-д. м. н., проф. Н. А. Шнайдер; кафедра поликлинической терапии и семейной медицины с курсом ПО, зав.-д. м. н., проф. М. М. Петрова; 2 ФГАОУ ВПО Северо-Восточный федеральный университет имени М. К. Аммосова Министерства образования и науки РФ, ректор-д. п. н., проф. Е. И. Михайлова; кафедра неврологии и психиатрии медицинского института, зав.-д. м. н. Т. Я. Николаева. v%+< (11+%$."-(?. Оценка компьютерной паллестезиометрии как перспективного метода диагностики демиелинизирующего поражения толстых волокон при сенсорной форме ХВДП. l 2%0(+; (,%2.$;. Обследовано 77 чел. с сенсорным вариантом ХВДП на базе Университетской клиники КрасГМУ им. проф. В.Ф.Войно-Ясенецкого. Возраст больных варьировал от 13 лет до 61 года, медиана возраста составила 30 лет. Методы диагностики: клинический неврологический, нейрофизиологический. p%'3+<2 2;. Модифицированная методика компьютерной паллестезиометрии с использованием отечественного диагностического оборудования «Вибротестер МБН» ВТ-02-1 является чувствительным методом диагностики сенсорной формой ХВДП, в том числе, на ранних стадиях развития заболевания и может быть рекомендована к широкому использованию в клинической практике. g *+>7%-(%. В дифференциальной диагностике степени тяжести сенсорных нарушений при ХВДП наиболее актуальным является исследование состояния вибрационной чувствительности с помощью метода компьютерной паллестезиометрии. j+>7%";% 1+." : хроническая воспалительная демиелинизирующая полиневропатия (ХВДП), диагностика, нейрофизиология, компьютерная паллестезиометрия.
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