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An analysis of the concentration of Mn in drinking water samples collected 425 of the Khanty-Mansiysk autonomous region: 228 from localities with high-quality drinking water purification and 198-with poor quality. Overstepping the MPC in most water samples with poor-quality clean it up. Content of Mn in investigated hair 468 adult residents of Khanty-Mansiysk autonomous region. Overstepping the average values of the element concentrations in hair of all those surveyed, significantly (p = 0.005) higher among residents of settlements with poor-quality drinking water purification. Excessive accumulation of Mn in human body, along with other factors, can potentiate the development of disease pathogenesis based on oxidative stress (primarily, cardiovascular), as well as thyroid disease, musculoskeletal system, iron deficiency anemia, etc.

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Aim: to study the concentration of Fe and Mn in the hair of women living in the cities of Khanty-Mansiysk Autonomous Region (KHMAO) with different treatment of drinking water. Methods. The ultimate composition of hair of 106 women (average age 38,9+11,3 g) - residents of the Northern region, not employed in the manufacturing sector was studied. 50 of them lived in the cities of Nefteyugansk and Nyagan and 56 - in the cities of Surgut and Khanty-Mansiysk. In the cities of Surgut and Khanty-Mansiysk underground water undergoes non chemical treatment, iron removal by the method of deep aeration and decontamination on UV irradiation installations. In the cities of Nefteyugansk and Nyagan water from artesian wells is decontaminated only by baclor. Results. The women living in the cities of Nefteyugansk and Nyagan had significantly higher (p < 0,001) and higher than reference values of Fe (82,3 + 11,4 mkg/g - the norm 7-40) and Mn (11,3 + 1,9 mkg/g - the norm 0,15-2,0) concentrations in the hair compared to women living in cities with high-quality purification of drinking water: Fe (23,6 + 2,2 mkg/g) и Mn (3,1 + 0,2 mkg/g). Iron, getting in to the organism with other pollutants (dietary Fe excess is not negative) also shows the properties of the immunosuppressant. Manganese is considered to be vital and at the same time a toxic element with mutagenic activity and tendency for accumulation. We can assume the best resistance to the adverse effects of oxidative stress in women-residents of KHMAO cities with optimal treatment of drinking water. Conclusions: To correct the microelement status of the Northern region population it is necessary to carry out more research of the environmental objects (in particular water) on the content of heavy metals, pay special attention to quality control of drinking water, and to use the method of microelement status determination of the hair chemical composition as an additional method of assessment of the internal body environment.

Element composition of hair of 102 expectant mothers, gave birth to a term 38-40 weeks has been studied. The main group included 52 women with fetus somatomegaly - (weight of a newborn is 4000 g and more), middle age - 29,6+8,4 The control group included 50 women with fetus normosomiya (weight of a newborn is from 2800 to 3999g ), middle age - 26,9+9,1 years. Bio-elements content, participating in carbohydrate and lipids metabolism namely Mg, Cr and Zn has been measured in the hair of expectant mothers using methods АЭС-PIC, МС-PIC. Statistically lower indices of Mg (p = 0,005) Cr (p = 0,010) and Zn (p = 0,004) concentration have been detected in expectant mothers with fetus somatomegaly in comparison with expectant mothers with fetus normosomiya. The expectant mothers with fetus somatomegaly more often had deviation from the physiologically optimal values of Mg, Cr and Zn concentration and deficiency of different degree of intensity as compared to the control group. Consequently, imbalance of macro and microelements of the organism can serve as one of starting mechanisms of pathological disorders, responsible for metabolic imbalance and diseases associated with it, in particular fetus somatomegaly in expectant mothers. Timely correction of macro and microelements imbalance can be considered as one of preventive variants of big fetation and along with other well-known methods of body weight optimization of expectant mothers become a preventive method of obstetric pathology development in mother and diseases associated with surplus body weight in a child.

Aim: to educe intercommunications between the indexes of carbohydrate-lipid exchange and trace elements, taking part in its adjusting for women with the somatomegaly of fruit, residents of the northern region. Methods. A study of biostandards of 102 expectant mothers performed delivery on term 38-40 weeks, residents of Khanty-Mansiysk for more than 5 years (52 - with the somatomegaly of fruit and 50 - a normosomy of fruit): blood indexes of carbohydrate-lipid exchange were studied by fermentation, calorimetric and photometric methods, and in hair -concentration of Zn, Cr Mg were studied by the methods of ICP-AES, МС-AES. Results. We detected statistically higher indexes of concentration of glucose (р < 0,001), ОХС (р = 0,012), thyroglobulin (р = 0,016), VLDL (р = 0,002), LDL (р = 0,002), KA atherogenic index (р

Background: Water is a key source of life on Earth; it is involved in the transfer of nutrients, macro- and microelements between soil, plants, animals and humans, as well as in the concentration and dispersion of chemical elements and the formation of minerals. The elemental status of the population is largely determined by the chemical composition of the natural waters on the territory of residence. Objective: To perform a comparative analysis of the concentrations of iron, manganese, calcium and magnesium in natural waters of the Khanty-Mansiysk and Yamalo-Nenets Autonomous Districts (Okrugs). Materials and methods: We established concentrations of iron, manganese, calcium and magnesium in 100 samples of natural waters taken from rivers, lakes, backwaters, channels, etc. of the Khanty-Mansiysk and Yamalo-Nenets Autonomous Districts, 50 samples each, using spectrophotometry, capillary electrophoresis and atomic absorption spectrometry. The results obtained were compared with the reference values provided in Russian sanitary rules and regulations SanPiN 1.2.3685–21. Results: We established elevated levels of iron in most surface water samples from both districts and of manganese in the Khanty-Mansi Autonomous Okrug accompanied by extremely low concentrations of Ca and Mg in the vast majority of all samples. At the same time, we registered significantly lower concentrations of Ca (p = 0.012) and Mg (p = 0.021) in the water samples from the Yamalo-Nenets Autonomous Okrug compared to those from the other district. Conclusion: In the population of the Tyumen North, the constant use of such water for drinking purposes can lead to the early development and rapid progression of cardiovascular and osteoarticular diseases, type 2 diabetes, neoplasms, etc.; at the same time, people are at risk of generalization of immunosuppressive conditions, diseases of the central nervous system, gastrointestinal tract, oxidative metabolism disorders, etc.

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