The voriconazole maintenance dose of 100 mg twice daily or 200 mg daily orally or intravenously may be inappropriate in patients with Child-Pugh class C cirrhosis because of the higher voriconazole C and higher incidence of adverse events. Monitoring voriconazole C earlier is extremely important to prevent the occurrence of voriconazole-related adverse reactions.
Stereotaxic biopsy was performed in 17 pts (71%); 9 (53%) had grade II diffuse astrocytoma, and 3 (18%) pilocytic astrocytoma; glioblastoma (GBM) was found in 1 patient at diagnosis and in another at a late recurrence of a glial proliferation. Pons and bulb were the main sites of the tumor (N¼10/10). Among the 21 treated pts, all underwent radiotherapy (RT); 7 received sequential radiotherapy and chemotherapy (RT+CT). Median OS was 45.2 months and 5-y OS was 48.7% (95% CI 24.5-69.2%). No statistically significant association was found between OS and age, tmt modality, or MRI contrast enhancement. ECOG-PS 3-4 was identified as negative PF; although no statistically significant, there was a numerical difference of outcomes regarding histological grade (Table ).Conclusions: Diagnosis of BG using stereotaxic biopsy may be more feasible than historically assumed and diverse histologies were identified. ECOG-PS 3-4 was a negative prognostic factor. Multicenter collaborative efforts are warranted for a better evaluation of PFs, including molecular profile.Legal entity responsible for the study: The authors.
respectively. CNR of 3D sequence was significantly higher (P<0.001) than that of 2D sequence. The median volume of HR CTV/GTV in 3D and 2D sequences was 18.3 ml/5.6 ml and 17.9 ml/7.3 ml, respectively. The median DICE coefficients were 79.5% for the HR CTV and 67.5% for GTV. The median D90 of HR CTV in each sequence was 8.4 Gy and 8.8 Gy, respectively. The median V100 of HR-CTV in each sequence was 97.9 ml and 100.2 ml, respectively. Conclusion: To the best of our knowledge, this is the first study that quantitatively evaluated the contrast of 3D MRI compared with 2D T2w FSE. Results support the clinical feasibility of our new 3D MRI technique in the IGBT for cervical cancer.
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