Application of CT-Guided Ad-P53 Intratumoral Injection for Recurrent and Metastatic Gynecologic Cancer Patients Who Received Chemoradiation Therapy

Abstract

respectively. CNR of 3D sequence was significantly higher (P<0.001) than that of 2D sequence. The median volume of HR CTV/GTV in 3D and 2D sequences was 18.3 ml/5.6 ml and 17.9 ml/7.3 ml, respectively. The median DICE coefficients were 79.5% for the HR CTV and 67.5% for GTV. The median D90 of HR CTV in each sequence was 8.4 Gy and 8.8 Gy, respectively. The median V100 of HR-CTV in each sequence was 97.9 ml and 100.2 ml, respectively. Conclusion: To the best of our knowledge, this is the first study that quantitatively evaluated the contrast of 3D MRI compared with 2D T2w FSE. Results support the clinical feasibility of our new 3D MRI technique in the IGBT for cervical cancer.