At the Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan, a number of scientists conducted extensive pharmaco-toxicological studies to study the biological activity of vincane hydrochloride and its derivatives. Based on these studies, a number of studies were conducted not only on the special pharmacological activity of the substances studied, but also on their effects on organs and systems, including respiration and blood pressure. Based on the conducted studies, it was found that in acute experiments on cats, vincanin hydrochloride and derivatives in doses of 0.3 – 5.0 showed a tendency to increase blood pressure and somewhat increased breathing. However, at higher doses, tonic clonic seizures occurred, leading to the death of experimental animals. This requires the use of these substances in very small doses, as far as possible, in order to achieve a therapeutic effect. In studies of changes in the body weight of experimental animals in dynamics, vincanin hydrochloride and pyrosaline chloride did not have a negative effect on the ratio between the control group, although they slightly changed the weight of animals, while pyrosaline iodomethylate did not have a negative effect on the change in body weight of experimental animals in dynamics compared with vincanin hydrochloride and pyrosaline chloride.
In this article, as a continuation of scientific research on the study of the neurological activity of newly synthesized compounds, the results of studies of the neutropic activity of the 1,2,4 triazole derivative are presented. At the same time, the motor and search activity of compound D-378 was studied in the study conditions, the effect on M-cholinergic receptors in the arecoline tremor method, the effect on catalepsy with haloperidol, and anxiolytic activity. Studies have shown that the compound D-378 exhibits m-cholinomimetic and anxiolytic activity, and also increases the motor and search activity of animals without affecting the catalepsin of gloperidol. This, in turn, requires extensive scientific studies of other neurological activities of the D-378 compound.
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