Evaluation of the Effect of Vincanin Hydrochloride and Its Derivatives on Blood Pressure and Respiration Under Experimental Conditions

Abstract

At the Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan, a number of scientists conducted extensive pharmaco-toxicological studies to study the biological activity of vincane hydrochloride and its derivatives. Based on these studies, a number of studies were conducted not only on the special pharmacological activity of the substances studied, but also on their effects on organs and systems, including respiration and blood pressure. Based on the conducted studies, it was found that in acute experiments on cats, vincanin hydrochloride and derivatives in doses of 0.3 – 5.0 showed a tendency to increase blood pressure and somewhat increased breathing. However, at higher doses, tonic clonic seizures occurred, leading to the death of experimental animals. This requires the use of these substances in very small doses, as far as possible, in order to achieve a therapeutic effect. In studies of changes in the body weight of experimental animals in dynamics, vincanin hydrochloride and pyrosaline chloride did not have a negative effect on the ratio between the control group, although they slightly changed the weight of animals, while pyrosaline iodomethylate did not have a negative effect on the change in body weight of experimental animals in dynamics compared with vincanin hydrochloride and pyrosaline chloride.

Evaluation of the Effect on the Nervous System of Substances with an Alkaloid Structure Having Antitumor Activity

“…As a direct continuation of these scientific studies, antitumor, as well as general pharmaco-toxicological properties of indole alkaloids are studied [1,2]. In the course of the research work, the properties of the indole alkaloids vincanin, pyrazoline iodine methylate and pyrosline chloride were studied, such as the features of acute toxicity and acute toxicity in various laboratory animals [3,4], the effect on cardiovascular, respiratory organs [5], as well as the effect on the general condition of experimental animals [6]. In this regard, within the framework of scientific studies of the effect of these alkaloids on the nervous system, screening studies of their sleep-inducing and calming activity were conducted under experimental conditions.…”