SUMMARYThe frequency of occurrence of melaninless asporogenous variants with higher antibiotic-producing activity in populations of Streptomyces glomeratus, a producer of beromycins, increased by more than I00-200 times as a result of treatment with plasmid-curing agents (acridine orange 02 acriflavine), whereas ultraviolet light and nitrous oxide were less effective in this regard.
Spontaneous variants of the beromycin-producing strain Streptomyces glomeratus 3980 were divided into five groups (A-E) according to increasing antibiotic activity. The most active variants (group E) differed from the other types and the wild strain by a suppressed ability to produce aerial mycelium and melanoid piogment and by an increased production of propionic acid. Strains with a 12-fold higher antibiotic production capacity (with respect to strain 3980) were obtained by selection of superior segregants from submerged cultures of the E type.
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