Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities--echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by asperentin which had antibacterial and antifungal effects and, at a concentration of 86 microgram/ml, caused 50% mor7 tality in Artemia saline larvae. The highest cytotoxicity towards HeLa cells was found in physcion which caused 50% growth inhibition at a concentration of 0.1 microgram/ml.
A new metabolite was isolated from the culture of Penicillium rugulosum and its structure was determined from physico-chemical data. Accompanying metabolites skyrin and rugulosin were characterized by UV, IR, CD, mass and NMR spectra.
Summary. Two pigments responsible for the yellow-orange color of a brown conidiating mutant of the deuteromycete Trichoderma viride were isolated and spectroscopically identified as 1,3,6,8-tetrahydroxyanthraquinone (I) and 1-acetyl-2,4,5,7-tetrahydroxy-9,10-anthracenedione (II). Both compounds are known substances but were not yet reported as metabolites of this fungal species.Their relationship to other anthraquinones produced by T. viride is discussed. Key words. Trichoderma viride ; conidiating mutant; anthraquinones.The wild type of the deuteromycete Trichoderma viride produces dark-green conidia. Their formation is induced by light pulses t. Using UV radiation, a series of mutants were prepared, belonging either to the non-conidiating or to the conidiating types. The conidia of the latter type mutants are white, yelow or brown 2-4. One mutant of the last type was found to accumulate indicatorlike pigments both during and after conidiation.A stationary culture of T. viride mutant CCM F-742 was grown
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