The role of a number of clinical and laboratory indicators as possible predictors is analyzed
type of myocardial remodeling in patients with acromegaly. Specific anamnesis data were revealed,
levels of somatotropin, insulin-like growth factor-1, prolactin in the blood, as well as melatonin excretion, which promote the development of different types of myocardial remodeling. Results
are presented in the form of prognostic estimates, the use of which makes it possible to improve early
diagnosis of acromegaloid cardiomyopathy and prognosis for the patient by using modern
pharmacological correction.
The adiponectine, leptin and insulin levels in both sex obese patients 11-43 years old were under investigation. Such factor as body mass at birth was considered the main cause of adipocytokine’s alteration and insulin resistance development. It was proved that individuals born with low (< 2499 gr) and high (> 4000 gr) body mass are at risk to have decreased level of adiponectine and increased level of leptin. In turn above mentioned alteration of adipocytokines level may lead to insulin resistance development.
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