The adiponectine, leptin and insulin levels in both sex obese patients 11-43 years old were under investigation. Such factor as body mass at birth was considered the main cause of adipocytokine’s alteration and insulin resistance development. It was proved that individuals born with low (< 2499 gr) and high (> 4000 gr) body mass are at risk to have decreased level of adiponectine and increased level of leptin. In turn above mentioned alteration of adipocytokines level may lead to insulin resistance development.
Clinical examination of 369 obese boys of age 10–17 revealed that the majority of overweightpatients noted a number of complaints, among which the most common were headache, increasedappetite, thirst, decreased performance and progress at school. The following clinical features at ashort enough anamnesis were typical for boys in their early puberty: accelerated puberty, increasedblood pressure, diffuse goiter of the 1st dg, striae on the skin. Against the background of diseasemanifestation among adolescents we observe increased rate of abdominal obesity, hypertension,accelerated puberty, diffuse goiter 1st and 2nd dg. The combination of such symptoms as abdominalobesity and hypertension as components of the metabolic syndrome provides a basis for a moredetailed examination of this group of patients.
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