Osteoporosis constitutes one of the major public health problems in Russia and all over the world; this pathology has showed a tendency toward growth in recent decades. In Russia, osteoporosis was detected in 30.5-33.1% of women aged 50 years and older who underwent densitometry examination, and the incidence of proximal femur fracture for persons over the age of 50 years averages to 105.9 per 100 000. Objective of the study: evaluation of the efficacy of osteo activ in the prevention and treatment of postmenopausal osteoporosis. Materials and methods of the study: 58 postmenopausal patients were examined. In addition to general clinical examination, the concentration of total and ionized Ca, as well as vitamin D in blood plasma were determined in all patients. All examined patients were divided into two groups according to the “case-control” principle: the first group (the main group) included 35 patients who were prescribed osteo activ for the purpose of treating and preventing postmenopausal osteoporosis; the second group (the comparison group) included 23 patients, whose diet was corrected in accordance with the daily requirement of calcium and vitamin D. Results of the study: The study showed a significant increase in the calcium and vitamin D concentration in the blood plasma and a decrease in pain syndrome against the background of the therapy in patients of the main group.
According to last research, receptors for vitamin D are found in many organs and tissues. Vitamin D deficiency leads to the development of pathological conditions in children and adults. The non-classical effects of vitamin D are important in modulating congenital and acquired immunity, regulating cell proliferation, in the progress of diabetes, the pathology of the cardiovascular system, and autoimmune diseases. The inverse correlation between the level of 25(OH)D3 and the incidence of cancer has been determined. Vitamin D affects the course of pregnancy, and the decidual and placental tissues synthesize 1.25(OH)2D. Vitamin deficiency is found in pregnant women with preeclampsia and gestational diabetes. Timely diagnosis and adequate correction of the level of vitamin D in the blood reduces the risk of developing diseases.
Physiotherapy is an important component in the prevention and treatment of obstetric and gynecological pathology. Physical factors should be used as primary or secondary treatment methods. The effects of physiotherapy are based on the absorption of physical (electrical, radiation, magnetic, etc.) energy by living tissues. The result of treatment depends on the physical factor, the number and a single dose of the procedures received. The best is the use of physiotherapy during several procedures (course of treatment). In connection with the progress of science and technology, new methods of physiotherapy have appeared: magnetic, infrared-laser-therapy, ozone, impulse-low-frequence-physiopherapeutical-apparat (ILPHYSA)-therapy, extremely-hign-frequence(EHF)-therapy. These methods began widely to use in gynecology.
Introduction. Recurrent pregnancy loss is a pathological condition characterized by inevitable miscarriage before 22 weeks of pregnancy or at birth of a fetus below 500 g of weight. The causes of miscarriage are quite diverse, and viral infections, including herpesvirus infection (HVI), is one of the important etiological factors for the development of this pathology. Activation of herpesvirus infection (HVI) has an extremely adverse effect on the course of pregnancy. The issue of the mechanism of reactivation of herpes viruses (HS) and the role of toll-like receptors (TLR) in predicting the activation of latent HVI during pregnancy has been insufficiently studied until the present. The study is aimed at evaluating the possibilities of predicting the activation of latent herpesvirus infection during pregnancy.Materials and methods. A total of 110 pregnant women with different courses of HVI were examined. The examination included the study of the TLR expression level and measurement of the pro- and anti-inflammatory cytokine levels.Results and discussion. Given the high specificity of TLR8 and the interferon system (IFN) against viral antigens, it can be assumed that the activation of TLR and the development of early cytokine reactions prior to the detection of specific antibodies in patients with latent HVI are predictors of advanced herpes infection. The levels of TLR8 expression and concentration of IFN-γ and IL-10 at the local level in patients with latent BBVI can be regarded as predictors of the transition of HBV from the latent phase of the life cycle to the lytic phase.Conclusion. If HVI develops actively during pregnancy, the antiviral immune response cascade that underlie the natural immune response starts at the local level, regardless of the localization of the antigen, and only a breakdown of the compensatory and adaptive mechanisms leads to the implementation of a systemic antiviral immune response. This suggests the important role of HVI, especially of its active forms, in the suppression of immunity during pregnancy.
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