Global inequity in access to and availability of essential mental health services is well recognized. The mental health treatment gap is approximately 50% in all countries, with up to 90% of people in the lowest-income countries lacking access to required mental health services. Increased investment in global mental health (GMH) has increased innovation in mental health service delivery in LMICs. Situational analyses in areas where mental health services and systems are poorly developed and resourced are essential when planning for research and implementation, however, little guidance is available to inform methodological approaches to conducting these types of studies. This scoping review provides an analysis of methodological approaches to situational analysis in GMH, including an assessment of the extent to which situational analyses include equity in study designs. It is intended as a resource that identifies current gaps and areas for future development in GMH. Formative research, including situational analysis, is an essential first step in conducting robust implementation research, an essential area of study in GMH that will help to promote improved availability of, access to and reach of mental health services for people living with mental illness in low- and middle-income countries (LMICs). While strong leadership in this field exists, there remain significant opportunities for enhanced research representing different LMICs and regions.
Ovariectomized Wistar rats received orally 15 mg/kg of a phytoestrogen compound (genistein, daidzein, glycitein, black cohosh, angelica sin., licorice, vitex agnus) for 2 weeks to test its ability to modulate inflammatory microglia response. Microglial proliferation was tested by trypan blue and by absorbance. Serial supernatant sampling was performed for 24 h to check TNF-alpha, IL-beta, IL-6, and TGF-beta. LPS caused a time course increase of all cytokines, with IL-beta and TNF-alpha peaking at the 12th hour, whereas IL-6 and TGF-beta peaked at the 24 h observation. Rats fed with the phytoestrogen displayed a significantly lower level of proinflammatory cytokines and a higher level of TGF-beta, as shown also by Western blot analysis. This finding may offer promise in the field of nutraceutical intervention.
A rice PAL (phenylalanine ammonia-lyase) gene sequence ( rPAL-P5), which is highly similar to and likely the same as a previously described rice ZB8PAL gene, including the 5'-upstream and exon I coding regions of PAL, was isolated using PCR amplification. The expression of several PALs, including rPAL-P5, was strongly induced following inoculation with Pyricularia oryzae or treatment with a P. oryzae elicitor. To identify the promoter region induced by the P. oryzae elicitor, we constructed and subsequently transformed rPAL-P5 promoter deletion series into rice calli using particle bombardment. Results from both elicitor-inducible reporter gene and gel mobility shift assays demonstrated that the sequence -349 to -256 of the rPAL-P5 promoter includes a cis-element involved in the induction of P. oryzae.
A triangular grid method is presented to calculate propagation problems of elastic stress waves in 2-D orthotropic materials. This method is based on the dynamic equilibrium equations of the computational cells formed among the auxiliary triangular grids. The solution is obtained by calculating alternately the nodal displacements and the central point stresses of the spatial grids. The numerical results are compared with the corresponding solutions of the finite element method. Comparisons show that the triangular grid method yields a higher calculational speed than the finite element method. The stress concentrations are investigated from wave-field analyses when the stress wave propagates within an orthotropic plate with a hole. Finally, the presented numerical method is used to study the features of wave propagation and diffraction in a square orthotropic plate with a hole when an impact load is applied to the top of the plate.
IntroductionIt is well known that the methods for numerically simulating propagation problems of elastic stress waves are generally classified into finite element [1, 2], finite difference [3, 4] and boundary element methods [5]. The grid method [6, 7] provides a new approach for stress-wave propagation in elastic material with simple programming. This method incorporates the advantages of the finite element and finite difference methods and is similar to the finite element method in the discretization of a numerical mesh, and to the staggered grid difference scheme [8] in computation. Thus, there are no requirements for calculating and storing the stiffness matrix, so computational cost and memory requirements are small. The numerical results indicate that the grid method is an accurate and efficient numerical method for analyzing wave propagation problems.In this paper, we aim to develop an accurate, efficient and versatile numerical scheme for analyzing stress-wave propagation in orthotropic materials due to an impact load. We extend the grid method for modeling elastic stress-wave propagation in 2-D orthotropic materials. The angle , defined between the x axis of the global coordinates and the principal direction of an orthotropic material, can have any value. The algorithm formulation based on the triangular grids is discussed in detail. Numerical simulations are performed for the stress-wave
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