Based primarily on IGF-I and IGFBP-3 levels our data suggest that a GH replacement dose in young GH deficient adults in the order of 1-2 IU/m2 per day is adequate. This is a relatively low dose as compared to dose regimens in children and adolescents.

Nasally administered GH is absorbed to a significant degree from the nasal mucosa without obvious untoward effects in the short term. These data encourage further studies with nasal GH administration.

We studied pl111m11 OH levels during 24-h GH profl!n and flfter erglnlne stlmulnllon (ATT) l!lnd meuur•d dey and night urinary GH ucretlon (U-GH) and IGF-1 and-lltev ab In 40 prepubMel children (25 b oys/1 5 girls) wllh short tleture eher IUGR (deUned 11 e blrthlength < P3). Mean 7.5 (3• 11) Meen (SO) height SOS (H-SDS) end height velocity S DS (HV-SDS) we$-2.95 (0.62) and-\ .08 (0.97), respectively. Gli profile s w e re enety,edv.lth PULSAR RE SULTS (expre ued as mean(SO) velues): C ieuificf\lion MeenGH At ieeo.st 1 GH-No.{%) of Peak GH U-GH iGf-1 SDSo. o l proli!e 6 mU/1 20 mUll Petients dming ATI ,,UJdey 'No: mar 6 (15) 34.2 (12.0) 15.8 (7.0) 0 .29 (0.46)