The significance of hepatitis associated antigen (HAA) was studied by immunodiffusion techniques in 270 sporadic acute viral hepatitis cases in Greece. The antigen was detected in 94 (34.8%) cases. The incidence was higher in the early stages and declined later in the course of the disease. It was further demonstrated that there is no sex or age difference in the incidence of HAA, which is also independent from the severity of the disease as reflected in the SGPT activity. The cases were characterised by available detailed history as infectious hepatitis (IH) or serum hepatitis (SH). The HAA was detected in almost equal proportions in both types. Also, they did not differ in their mean geometrical titre of HAA or in the trend of decline of their incidence in the later stages of the disease.
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