Background: Basal cell carcinoma (BCC) is the most common skin cancer, which is highly damaging in its advanced stages. Computer-aided techniques provide a feasible option for early detection of BCC. However, automated BCC detection techniques immensely rely on handcrafting high-level precise features. Such features are not only computationally complex to design but can also represent a very limited aspect of the lesion characteristics. This paper proposes an automated BCC detection technique that directly learns the features from image data, eliminating the need for handcrafted feature design. Methods:The proposed method is composed of 2 parts. First, an unsupervised feature learning framework is proposed which attempts to learn hidden characteristics of the data including vascular patterns directly from the images. This is done through the design of a sparse autoencoder (SAE). After the unsupervised learning, we treat each of the learned kernel weights of the SAE as a filter. Convolving each filter with the lesion image yields a feature map. Feature maps are condensed to reduce the dimensionality and are further integrated with patient profile information. The overall features are then fed into a softmax classifier for BCC classification. Results: On a set of 1199 BCC images, the proposed framework achieved an area under the curve of 91.1%, while the visualization of learned features confirmed meaningful clinical interpretation of the features. Conclusion: The proposed framework provides a non-invasive fast BCC detection tool that incorporates both dermoscopic lesional features and clinical patient information, without the need for complex handcrafted feature extraction. K E Y W O R D S automated basal cell carcinoma detection, blood vessels, dermoscopy, feature learning, sparse autoencoders

Abstract-Irregular streaks are important clues for Melanoma (a potentially fatal form of skin cancer) diagnosis using dermoscopy images. This paper extends our previous algorithm to identify the absence or presence of streaks in a skin lesions, by further analyzing the appearance of detected streak lines, and performing a three-way classi cation for streaks, Absent, Regular, and Irregular, in a pigmented skin lesion. In addition, the directional pattern of detected lines is analyzed to extract their orientation features in order to detect the underlying pattern. The method uses a graphical representation to model the geometric pattern of valid streaks and the distribution and coverage of the structure. Using these proposed features of the valid streaks along with the color and texture features of the entire lesion, an accuracy of 76.1% and weighted average area under ROC curve (AUC) of 85% is achieved for classifying dermoscopy images into streaks Absent, Regular, or Irregular on 945 images compiled from atlases and the internet without any exclusion criteria. This challenging dataset is the largest validation dataset for streaks detection and classi cation published to date. The data set has also been applied to the two-class sub-problems of Absent/Present classi cation (accuracy of 78.3% with AUC of 83.2%) and to Regular/Irregular classi cation (accuracy 83.6% with AUC of 88.9%). When the method was tested on a cleaned subset of 300 images randomly selected from the 945 images, the AUC increased to 91.8%, 93.2% and 90.9% for the Absent/Regular/Irregular, Absent/Present, and Regular/Irregular problems, respectively.

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