Use of the eMAR application significantly reduces the rate of ME-MAR and their potential risk. The main cause of ME-MAR was the failure to follow work procedures.
The CPOE system almost completely eliminated MEs with antineoplastic drugs in the Haematology Department. No new types of MEs were observed once physicians had become accustomed to using the system. However, some MEs were not eliminated. Constant diligence is needed to analyse and evaluate MEs associated with the CPOE system and their causes, such that the limitations of CPOE can be identified and overcome and the medication-use process associated with antineoplastic agents improved.
antiretroviral treatment or switched to dual therapy based on lamivudine and dolutegravir between June 2018 and September 2019 were included. Study variables were age, sex, date and reason for the change, duration of treatment, viral load (CV, copies/mL), CD4 and CD8 cells (cells/mL) before and after the change and on the date of the last available analysis, previous therapy, glomerular filtration rate (GFR) (mL/min), and levels of cholesterol (mg/dL), low density lipoprotein (LDL, mg/dL) and triglycerides (mg/dL). Results Nine patients (66.66% men) with a mean age of 49 years (30-58), 3 of whom were naive patients (33.33%) were analysed. Effectiveness was 100% of patients who achieved CV <50 copies at 4-6 weeks, maintaining the virological response for an average of 26 weeks. CD4 and CD8 counts increased significantly from 690 to 805 and 910 to 943, respectively. The lipid profile showed differences in LDL from 170 to 120. A significant decrease in GFR was observed from 102 to 87. The annual cost saw a decrease of 1690C ¼ /patient/ year. Conclusion and relevance Simplification to dual therapy was a safe and effective option that allowed optimisation of the resources against triple therapy.
BackgroundControversy exists over the efficacy of oseltamivir; even the FDA and CDC disagree. We reviewed the available evidence on the efficacy of oseltamivir in both paediatric and adult populations. It was concluded that there is no justification for the use of oseltamivir in conditions other than those authorised: there is no statistically significant difference in efficacy between standard dose and double dose; neither are there studies specifically designed to evaluate the efficacy of oseltamivir beyond 5 days of treatment.PurposeTo evaluate the suitability of oseltamivir prescription according to the evidence available in hospitalised patients.Material and methodsAn observational retrospective study performed from 1 October 2014 to 30 April 2015 in a general hospital. It included paediatric and adult patients treated with oseltamivir during that period. Patients were identified through a computerised prescription order entry system (PrescriWin). We reviewed the medical records and registred age, gender, clinical service, posology, duration of treatment and estimated glomerular filtration rate (eGFR) using the MDRD-4 IDMS. We reviewed discharge reports in those patients who were discharged before the end of therapy with oseltamivir. All data were reviewed and evaluated for their suitability according to the available evidence.Results47 patients were treated with oseltamivir during the study period, 1 being excluded because it was not possible to gather the necessary information for the study. 37% were male and the average age was 68 years. 34 patients (74%) received oseltamivir according to the technical specifications of the European Medicines Agency (EMA). However, 15 discrepancies were found in 12 patients (26%). 2 patients (4%) received double dose therapy (150 mg/12 h) and 7 patients (15%) received oseltamivir for more than 5 days (only 2 of them were hospitalised in the ICU). In 8 cases, the eGFR was <60 mL/min, and in only 2 patients (25%) was the dose adjusted according to the EMA.ConclusionThe results of our study confirm that there was a large variation in oseltamivir prescription. A high percentage of patients received a regimen outside of the labelled recommendations.References and/or AcknowledgementsMcQuade B, Blair M. Influenza treatment with oseltamivir outside of labeled recommendations. Am J Health Syst Pharm 2015;134-8No conflict of interest.
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