1960), 'Veno-arterial Pumpinf: in Normal Does and Does with Coronarv Occlusion .

SUMMARY Twenty-one patients with rheumatoid arthritis received injections of either 40 mg or 80 mg of methylprednisolone acetate into one or both knee joints. Serum methylprednisolone and cortisol levels were measured at intervals up to 1 week following injection. Peak serum levels of methylprednisolone were reached at between 2 and 12 hours following injection, and increasing the injected dose resulted in correspondingly higher serum levels. Injection of 80 mg of methylprednisolone as 40 mg into each knee produced consistently higher peak serum levels than when given as a single intra-articular injection. Serum cortisol levels were substantially suppressed for up to 1 week. and this effect was seen at all dose levels.

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for the experiment. Throughout the study they were fed a pathogen-free balanced diet suitable for humans. Using strict aseptic precautions and with the animals sedated with phencyclidine or ketamine hydrochloride, 0 5 ml (20 mg) methyl prednisolone was injected into one knee joint of each animal. An equivalent volume of vehicle used in the same commercial preparation of methyl prednisolone was injected into the opposite knee. The vehicle consisted ofpolyethylene glycol 29 mg, sodium chloride 8f7 mg, mynistylgamma picolinium chloride 019 mg, and water to 1 ml. The accurate placing of the injections was confirmed by adding 0-2 ml of a radio-opaque dye (Conray) to the injection fluid and performing x-rays immediately after injection. Tibial biopsies were obtained from both knees of 2 animals 4 weeks later and injections were repeated at the same time in the other 8 animals. 4 of these underwent a further series of four injections into each knee at 2-week intervals (total of 6 injections). X-rays of the joints were taken immediately before the experiment and again 14 weeks later at which time all 10 animals were sacrificed.The surfaces of the femoral condyles, menisci, and tibiae were examined with the naked eye for surface defects. The fresh femoral specimens were coated with India ink diluted with physiological saline, examined for evidence of fibrillation in the manner described by Bullough and Goodfellow (1968) and then photographed.The biopsies and the whole joints were fixed in on 9 May 2018 by guest. Protected by copyright.

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