An open-label, 60-day trial was conducted in 75 newly diagnosed tuberculosis (TB) patients to assess the adjunctive effect of the oral immunomodulator Dzherelo with standard anti-TB chemotherapy (ATT) consisting of izoniazid, rifampicin, pyrazinamide and streptomycin (HRZS) administered as directly observed therapy (DOT). Group 1 (n = 28) with cavitary TB and group 2 (n = 17) with infiltrating pulmonary TB received 50 drops of Dzherelo twice daily in addition to HRZS. Group 3 (n = 30), which served as a control, received ATT only. Liver damage indicators, bilirubin, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) decreased to normal levels in groups 1 and 2, but increased significantly in group 3. Kidney failure markers, urea and creatinine, normalized in Dzherelo recipients, but were unchanged or worsened in the ATT-only group. The changes in serum lactate dehydrogenase, catalase, malondialdehyde and diene conjugates suggested that Dzherelo downregulates TB-associated inflammation. The anti-inflammatory property of Dzherelo was further supported by a favourable haematology profile, reduced erythrocyte sedimentation rate and faster defervescence. Radiological recovery was significant in both Dzherelo groups, but not in the control group (p = 0.0085, p = 0.025 and p = 0.23, respectively). These findings correlated positively with sputum smear conversion and clinical findings (r = 0.94; p < 0.05). Mycobacterial clearance at day 30 was observed in 77%, 72% and 40% of patients in groups 1, 2 and 3, respectively. After 2 months sputum conversion rates in groups 1, 2 and 3 were 93%, 89% and 70%, respectively. Sixty-day treatment outcomes in groups 1, 2 and 3 as assessed by improvement in clinical features and respiratory function attained respective p-values of 0.008, 0.25 and 0.72, and 0.013, 0.48 and 0.0015. Dzherelo is thus useful as an immunotherapeutic adjunct in the management of TB.
The study of the carcass muscles development was carried out on Simmental and Kazakh White-Headed steers and their first generation hybrids. At the age of 18 months, the control slaughter of 3 steers of different genotypes was carried out: I - Simmental, II - Kazakh White-Headed, III - 1/2 Kazakh White-Headed x 1/2 Simmental. To study the development of muscle groups and individual muscles by anatomical regions, the left half-carcasses were prepared, taking into account the methodical instructions. To facilitate the analysis of the material, the muscles were grouped according to the relevant joints and the topographic location by the generally accepted pattern. The muscles development was studied using the data on the absolute mass of individual muscles and muscle groups. It was established that the steers of group III surpassed those of groups I and II in the total muscle mass of the spinal column, which was 1.28-0.45 kg (10.85-3.56%), the total muscle mass of the shoulder girdle - 1.45-0.51 kg (9.78-3.51%), thoracic limb - 0.72-0.25 kg (9.77-3.43%), pelvic limb - 3.16-1.11 kg (9.78-3.45%) and, in general, throughout the half-carcass of the muscles considered - 6.62-2.33 kg (9.79-3.44%).
The development patterns of carcass muscles were studied on Simmental and Black-Spotted steers and their hybrids of the 1st generation. At the age of 18 months, a control slaughter of 3 steers of different genotypes was carried out: Group I - purebred Simmental steers; Group II - hybrids of ½ Simmentals x ½ Red Steppe steers; Group III - hybrids of ½ Simmentals x ½ Black-Spotted steers. To study the muscle groups and individual muscles development according to anatomical regions, the left half-carcasses were prepared, taking into account the methodological instructions, and to facilitate the analysis of the material, the muscles were grouped according to the joints associated with them and the topographic location, using the generally accepted scheme. The muscles development was studied on the basis of the absolute mass indices of individual muscles and muscle groups. It was established that steers of Group III had the following advantages over the animals of the same age in Groups I and II: in the total muscle mass of the spinal column the advantage was 217-772 g (1.43 - 18.30%), in the total muscle mass of the shoulder girdle - 1.45-0.51 kg (9.78-3.51 %), the thoracic limb - 231-660g (14.37-41.04%), the pelvic limb - 3.16-1.11 kg (9.78-3.45%) and in general for the entire half-carcass of the recorded muscles - 6.62-2.33 kg (9.79-3.44 %).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.