Many mud volcanoes are distributed along the tectonic sutures in southern Taiwan and can be divided into five zones based on their relative positions in different tectonic domains. Most active mud volcanoes are exhaling methane-dominated gases. Nevertheless, some gases show unusual carbon dioxide-dominated and/or nitrogen-excess compositions. This implies that there are multiple sources for the gas compositions of mud volcanoes in Taiwan. For better understanding the total amount of exhalation gases and its flux, the gas flow and compositions were continuously measured in the interval of two minutes at Chung-lun (CL) bubbling mud pool for a few months. The major compositions of gases exhaling from this site were 75$90% of CO 2 and 5$12% of CH 4 . The amount of gases exhaling from the mud pool can be estimated to be about 1.4 ton/year for CH 4 and 28 ton/year for CO 2 , respectively. The preliminary results of exhaling gas flux from the major vents of representative active mud volcanoes, yielded an estimated total CH 4 output of the mud volcanoes in Taiwan of ca. 29 ton/year during quiescent period.

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Background. The EACH study assessed the efficacy of oxaliplatin, 5-fluorouracil, and leucovorin (the FOLFOX4 regimen) compared with doxorubicin alone in terms of overall survival (OS), progression-free survival (PFS), and safety in patients with advanced hepatocellular carcinoma (HCC). We present the results of this study in Chinese patients. Methods. In a multicenter, open-label, randomized, phase III study (NCT00471965), 371 patients (279 patients from the People's Republic of China) were randomized 1:1 to receive either FOLFOX4 or doxorubicin until disease progression, intolerable toxicity, death, or surgical resection. Results. Baseline characteristics of the Chinese patients enrolled in the study were similar for the 2 treatment groups and in comparison with the whole EACH cohort. Median OS at the prespecified time point of treatment was 5.7 months with FOLFOX4 and 4.3 months with doxorubicin (hazard ratio [HR]:

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Abstract:Polygonum cuspidatum is widely used as a medicinal herb in Asia. In this study, we examined the ethyl acetate subfraction F3 obtained from P. cuspidatum root and its major component, emodin, for their capacity to inhibit the Epstein-Barr virus (EBV) lytic cycle. The cell viability was determined by the MTT [3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyltetrazolium bromide] method. The expression of EBV lytic proteins was analyzed by immunoblot, indirect immunofluorescence and flow cytometric assays. Real-time quantitative PCR was used to assess the EBV DNA replication and the transcription of lytic genes, including BRLF1 and BZLF1. Results showed that the F3 and its major component emodin inhibit the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces EBV DNA replication, showing that F3 and emodin are potentially useful as an anti-EBV drug.

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