Magnetite nanoparticles (NPs) decorated with silver (magnetite/Ag) are intensively investigated due to their application in the biomedical field. We demonstrate that the increase of silver content on the surface of nanoparticles improves the adsorptivity of antibiotic rifampicin as well as antibacterial properties. The use of ginger extract allowed to improve the silver nucleation on the magnetite surface that resulted in an increase of silver content. Physicochemical and functional characterization of magnetite/Ag NPs was performed. Our results show that 5%-10% of silver content in magnetite/Ag NPs is already sufficient for antimicrobial properties against Streptococcus salivarius and Staphylococcus aureus. The rifampicin molecules on the magnetite/Ag NPs surface made the spectrum of antimicrobial activity wider. Cytotoxicity evaluation of the magnetite/Ag/rifampicin NPs showed no harmful action towards normal human fibroblasts, whereas the effect on human embryonic kidney cell viability was time and dose dependent.
3 UDC 620.193.8Nanosized iron-based powders of different compositions and particle sizes have been developed for medical application. It is shown that their structural and phase compositions, which are related to their magnetic properties, can be controlled. The interaction of the powders with model media such as human blood plasma and its mixture with 0.9% NaCl solution (1 : 1), distilled water, and 0.9% NaCl solution is studied. The rate of powder dissolution in blood plasma is established to depend on the α-iron content and particle size: the higher these parameters, the more intensive the powder biotransformation. The Fe 3 O 4 powders are quite resistant to model biomedia: their solubility in media containing blood plasma is one-hundredth to seven-thousandths of α-Fe solubility.
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