The present study considered the influence of various factors on the catalytic activity of systems based on a combination of tetrakis(oxodiperoxotungsto)phosphate(3-) with quater nary ammonium cations, for example, with methyltri n octylammonium [Me(n C 8 H 17 ) 3 N] + . The catalysts were tested in oxidation of cycloolefins (cyclohexene and cyclooctene), alcohols (octan 1 ol and phenylmethanol), and unsaturated fatty acids (cis 9 octadecenoic and 12 hydroxy 9Z octadecenoic acids) with a 30% hydrogen peroxide solution. These reactions proceed under mild conditions (atmospheric pressure, 80-90 °C) to give carboxylic acids. The catalytic systems were characterized by vibrational (IR and Raman) spectroscopy. The state of the systems formed from various precursors, viz., polyoxometallates and phase transfer cata lysts, was studied. It was demonstrated for the first time that the structure formation of peroxo complexes depends on the nature of the halide anion of the quaternary ammonium salt used. The melting points of individual catalytic complexes were determined. The optimal conditions for oxidation were found.
Methyl esters of monounsaturated fatty acids were oxidized with aqueous hydrogen peroxide in biphasic organic-aqueous systems in the presence of catalyst [Me(n-C 8 H 17 ) 3 N] 3 {PO 4 [WO(O 2 ) 2 ] 4 }. Epoxidation and oxidative cleavage of the C=C bond were found to proceed with high conversion and selectivity in the absence of organic solvents and under rather mild conditions (T \ 100°C, 1 atm).
In this paper, a series of novel abietyl and dehydroabietyl ureas, thioureas, amides, and thioamides bearing adamantane moieties were designed, synthesized, and evaluated for their inhibitory activities against tyrosil-DNA-phosphodiesterase 1 (TDP1). The synthesized compounds were able to inhibit TDP1 at micromolar concentrations (0.19–2.3 µM) and demonstrated low cytotoxicity in the T98G glioma cell line. The effect of the terpene fragment, the linker structure, and the adamantane residue on the biological properties of the new compounds was investigated. Based on molecular docking results, we suppose that adamantane derivatives of resin acids bind to the TDP1 covalent intermediate, forming a hydrogen bond with Ser463 and hydrophobic contacts with the Phe259 and Trp590 residues and the oligonucleotide fragment of the substrate.
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