Natural endogenous compound g-L-glutamylhistamine (g-GHA) and its analogs g-aminobutyrylhistamine and N b -glutarylhistamine were synthesized using peptide chemistry methods. The experiments in vivo on mice bearing a model of hypoxia with hypercapnia showed that all the synthesized compounds exhibit more or less pronounced antihypoxic activity. The most significant effect (150% relative to control) was observed for g-GHA in a dose of 0.01 mg/kg, which is 2´10 4 times smaller than the effective dose of the reference drug sodium oxybutyrate. 122 0091-150X/05/3903-0122
Peptides U 0400Synthesis and Antihypoxic Activity of γ-L-Glutamylhistamine and Its Derivatives.-The synthesis of γ-L-glutamylhistamine as well as its derivatives N β -glutarylhistamine and γ-aminobutyrylhistamine is achieved using standard peptide chemistry. Among the three compounds tested, best antihypoxic activity is achieved for γ-L-glutamylhistamine. -(KROMOVA, T. A.; ZHELTUKHINA, G. A.; NEBOL'SIN, V. E.; KOVALEVA, V. L.; KRZHECHKOVSKAYA, V. V.; EVSTIGNEEVA, R. P.; Khim.-Farm. Zh. 39 (2005) 3, 12-15; Lomonosov State Acad. Fine Chem. Technol., Moscow 117571, Russia; Russ., Abstr. Eng.) -Mischke 30-173
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