Context: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity, characterized by inflammation and progressive fibrosis of the submucosal tissues. The main agent involved in the pathogenesis of OSMF is areca nut. A wide range of treatment, including drug management, surgical therapy, and physiotherapy, has been attempted till date, with varying degrees of benefit. Aims: The objective of this study was to assess efficacy of curcumin for the treatment of OSMF; to asses efficacy of topical steroids for the treatment of OSMF; and to compare the efficacy of curcumin and topical steroid for the treatment of OSMF. Setting and Design: Participants were assessed based subjective and objective feature of OSMF, i.e., burning sensation of the oral cavity and interincisal distance, respectively. Methodology: Thirty participants were categorized into two groups: Group A was administered curcumin and Group B was administered topical steroids for a period of 3 months and followed up after 6 months. The assessment was based on maximal incisal opening and burning sensation for spicy food on Visual Analog Scale score. Analysis: Independent t test was applied for comparison within the group, ANOVA Bonferroni post hoc test was applied for multiple comparison of mean and Mann–Whitney U test was applied to compare the groups. Results: The statistical analysis revealed curcumin to be more efficient than topical steroid. Conclusion: The present study demonstrates the efficiency of curcumin and topical steroid to alleviate the clinical findings of OSMF. However, curcumin is comparatively more efficient than steroids for the treatment of OSMF.
Background Lichen planus (LP) is a common long term inflammatory disorder that affects skin and mucous membranes. Though mostly asymptomatic in oral mucosa it may cause severe morbidity in erosive cases. The relation between LP and liver diseases especially hepatitis C have been proposed by many authors with varied results. Alteration in liver function tests reflected by increased levels of transaminase levels, i.e., serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) with or without the presence of antibodies against hepatitis C virus (HCV) has been observed in oral lichen planus (OLP) patients in many studies. So this study was undertaken with the intent to further evaluate any alliance between OLP and liver disease principally hepatitis C. Materials and methods The study consisted of 30 histopathologically confirmed patients of OLP and 30 age and sex matched healthy volunteers visiting the outpatient department of a dental hospital over a period of 1 year. All subjects in both groups were subjected to SGOT, SGPT and HCV antibodies detection. Results The percentage of patients with elevated SGOT and SGPT values was higher among the OLP patients in the study group (40%) in comparison to subjects in the control group (7%). The mean values of SGOT and SGPT were also higher in the study group in comparison to the control group. No HCV antibodies were found in the serum of subjects in both the study group and control group. Conclusion Liver disease or hepatitis C can be considered a risk factor for LP and may lead to diagnosis, early treatment and possibly a better prognosis in asymptomatic OLP patients. Further studies with large samples are recommended to prove the current hypothesis regarding the association between LP and chronic liver disease and/or HCV infection. How to cite this article Sobti G, Manjunath M, Deepak TA, Krishna S, Annaji AG. Oral Lichen Planus in Relation to Transaminase Levels and Hepatitis C Viral Antibodies Detection: A Clinical Study. World J Dent 2016;7(2):64-68.
Context: Oral submucous fibrosis (OSMF) is chronic, scarring disease of the oral cavity. Cytokines and growth factors produced by inflammatory cells play a major role in its pathogenesis. Low-level laser therapy (LLLT) application, which has an anti-inflammatory, was used to determine the improvement in mouth opening. Aims: The aim of the study is to evaluate the effectiveness of laser photobiomodulation (PBM) in OSMF treatment. Materials and Methods: Thirty patients who were diagnosed with OSMF after obtaining consent form and ethical clearance were included. LLLT was applied for 4 cycles for 15 s each in the left and right buccal mucosa. Therapy was done on day 0, 3, 7, and 15 and measurements were done immediately after each LLLT application. Patients were recalled after 1, 3, and 6 months from the commencement of the therapy for follow-up measurements. Results: The mean increase in mouth opening following application of LLLT from day 0 to day 15 was 9.91 ± 3.34, and day 1–6 months was 14.29 ± 6.82, which was statistically significant. Conclusions: The study shows significant improvements in the mouth opening of the OSMF patient during treatment and postoperatively. Thus, our study confirms LLLT can be used as one of the modality in OSMF management.
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