Context: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity, characterized by inflammation and progressive fibrosis of the submucosal tissues. The main agent involved in the pathogenesis of OSMF is areca nut. A wide range of treatment, including drug management, surgical therapy, and physiotherapy, has been attempted till date, with varying degrees of benefit. Aims: The objective of this study was to assess efficacy of curcumin for the treatment of OSMF; to asses efficacy of topical steroids for the treatment of OSMF; and to compare the efficacy of curcumin and topical steroid for the treatment of OSMF. Setting and Design: Participants were assessed based subjective and objective feature of OSMF, i.e., burning sensation of the oral cavity and interincisal distance, respectively. Methodology: Thirty participants were categorized into two groups: Group A was administered curcumin and Group B was administered topical steroids for a period of 3 months and followed up after 6 months. The assessment was based on maximal incisal opening and burning sensation for spicy food on Visual Analog Scale score. Analysis: Independent t test was applied for comparison within the group, ANOVA Bonferroni post hoc test was applied for multiple comparison of mean and Mann–Whitney U test was applied to compare the groups. Results: The statistical analysis revealed curcumin to be more efficient than topical steroid. Conclusion: The present study demonstrates the efficiency of curcumin and topical steroid to alleviate the clinical findings of OSMF. However, curcumin is comparatively more efficient than steroids for the treatment of OSMF.
Introduction: Infantile hemangiomas are the most common benign vascular tumors of infancy. The prevalence is around 3-10%. The various risk factors include female gender, prematurity, low birth weight, multiple pregnancies, advanced maternal age and in vitro fertilization. IH most commonly affect the head and neck region. This study aims to give an insight and highlight the evidence-based approach in the management of IH. To assess the occurrence, plan Aim: of management and the interventions in the management of hemangiomas occurring in children. This study used a retrospective observational m Method: ethod to assess and evaluate the various interventions employed in the management of infantile hemangiomas between July 2021 and February 2022. A total of 50 patients were Result: included in the study, 30 were females and 20 males. 15 lesions were surgically treated, 5 underwent laser ablation and remaining 30 were treated with beta blockers and corticosteroids. The primary outcome measures were clearance, a subjective measure of improvement, and adverse events. Secondary outcomes were other measures of resolution; aesthetic appearance; and requirement for surgical correction. The Outcome: treatment of IH depends on the following factors: Type of hemangioma, stage of the lesion, location and extent, number and distribution of the lesion, associated systemic involvement, presence or absence of ulceration and psychosocial distress of the parents or child. In general, any function threatening (ocular, ear, nasal tip, lip, large disguring facial lesion and genitalia involvement) or life-threatening hemangioma, need intervention. The remaining cases need only active non-intervention, like education about the natural course, treatment options and anticipatory guidance. Systemic corticosteroids are used for complicated hemangiomas, followed by non-selective beta-blockers, such as oral propranolol and topical timolol can be used for uncomplicated localized lesions.
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