Background: Recently, it has been reported that frequent premature ventricular contractions (PVCs) may be associated with causing heart failure in patients with left ventricular (LV) dysfunction. However, the prognostic significance of frequent PVCs in asymptomatic patients with a normal LV function is unclear.

Establishment of sedimentary sequence is essential for the interpretation of the sedimentary records. Integrated Ocean Drilling Program (IODP) Expedition (Exp.) 346 drilled high-quality sediment archives with more than three holes each at nine sites that enable us to establish continuous sedimentary sequences through splicing technique. After extensive efforts to replace the disturbed, missed, or duplicated intervals found in spliced sediment sequences constructed onboard during IODP Exp. 346 to the corresponding undisturbed intervals, nearly perfectly continuous sediment columns and physical property records for the Pleistocene intervals of Sites U1422-U1427 and U1430 collected from the Japan Sea have been established. Same kind of efforts to correct the shipboard splices were also achieved for Plio-Miocene intervals at Sites U1425 and U1430. The continuous records established for these sites will allow a much more detailed understanding of the long-term variability in East Asian paleoclimate and North Pacific oceanography.

For follow-up after coiling with an Enterprise stent, CE-MRA may be necessary to avoid susceptibility artifacts caused by the stent.

The PV-LA voltage on the PV-encircling ablation line and FTI/PV-LA voltage were related to the acute post-PVI PV reconnections. A more durable ablation strategy is warranted for high-voltage zones.

Background: It is not clear what kind of drug is appropriate to heal forNSAIDs-induced enteropathy. Several reports showed the preventive effect of prostaglandin analogue or inducer using healthy subjects who took NSAIDs. However there was no report for healing effect and for patients. The aim of this study was to evaluate the healing effect of rebamipide in patients with NSAIDs-induced enteropathy.In addition, we evaluated for nutritional parameter. Methods: This study was conducted as a randomized, double-blinded, placebo-controlled, multicenter trial. Study protocol was approved by each hospital's ethical committees. Patients with LDA and/or NSAID more than 3 month were enrolled.Patients with enteropathy were divided into the placebo and the rebamipide groups.Rebamipide 100mg three times daily was administered during 4 weeks. Capsule endoscopies were performed at 0 and 4 week. The number of small intestinal ulcer and erosion were evaluated. Total protein was analyzed as nutritional parameters.

In cryptorchid testes there is a decreased number of spermatogonial stem cells in which FoxO1 is activated, indicating that failure of spermatogonial stem cell maintenance results in spermatogenesis alteration. We also noted interaction between miR-135a and FoxO1, and propose that miR-135a contributes to spermatogonial stem cell maintenance through modulation of FoxO1 activity.

CE is useful for the evaluation of small bowel mucosal injuries in Japanese patients with sCD and eCD. Possible intestinal stricture needs to be carefully evaluated before CE even in patients with sCD.

Although HBA lesions appear to be smaller than CBA lesions, middle-term outcomes are not statistically different between these balloon modalities.