Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has emerged as a pandemic. Paucity of information concerning the virus and therapeutic interventions have made SARS-CoV-2 infection a genuine threat to global public health. Therefore, there is a growing need for understanding the molecular mechanism of SARS-CoV-2 infection at cellular level. To address this, we undertook a systems biology approach by analyzing publicly available RNA-seq datasets of SARS-CoV-2 infection of different cells and compared with other lung pathogenic infections. Our study identified several key genes and pathways uniquely associated with SARS-CoV-2 infection. Genes such as interleukin (IL)-6, CXCL8, CCL20, CXCL1 and CXCL3 were upregulated, which in particular regulate the cytokine storm and IL-17 signaling pathway. Of note, SARS-CoV-2 infection strongly activated IL-17 signaling pathway compared with other respiratory viruses. Additionally, this transcriptomic signature was also analyzed to predict potential drug repurposing and small molecule inhibitors. In conclusion, our comprehensive data analysis identifies key molecular pathways to reveal underlying pathological etiology and potential therapeutic targets in SARS-CoV-2 infection.

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This study assessed the preparedness regarding the preventive practices toward the coronavirus disease 2019 (COVID-19) among the adult population in Bangladesh. Data were collected through an online survey with a sample size of 1,056. We constructed four variables (individual, household, economic, and community and social distancing) related to preparedness based on the principal component analysis of eight items. We employed descriptive statistics and multiple linear regression analysis. The results showed that the accuracy rate of the overall preparedness scale was 68.9%. The preparedness level related to economic, individual, household, and community and social distancing was 64.9, 77.1, 50.4, and 83.2%, respectively. However, the economic preparedness significantly varied by sex, education, occupation, attitude, and worries related to COVID-19. Individual preparedness was significantly associated with education, residence, and attitudes. The household preparedness significantly varied by education, residence, and worries, while the respondent's community and social distancing-related preparedness significantly varied by sex, region, residence, and attitude. This study implies the necessity of the coverage of financial schemes for the vulnerable group. Increased coverage of health education regarding personal hygiene targeting the less educated and rural population should be ensured.

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Third-party package usage has become a common practice in contemporary software development. Developers often face different challenges, including choosing the right libraries, installing errors, discrepancies, setting up the environment, and building failures during software development. The risks of maintaining a third-party package are well known, but it is unclear how information from Stack Overflow (SO) can be useful. This paper performed an empirical study to explore npm package co-usage examples from SO. From over 30,000 SO question posts, we extracted 2,100 posts with package usage information and matched them against the 217,934 npm library package. We find that, popular and highly used libraries are not discussed as often in SO. However, we can see that the accepted answers may prove useful, as we believe that the usage examples and executable commands could be reused for tool support.

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The package manager (PM) is crucial to most technology stacks, acting as a broker to ensure that a verified dependency package is correctly installed, configured, or removed from an application. Diversity in technology stacks has led to dozens of PMs with various features. While our recent study indicates that package management features of PM are related to end-user experiences, it is unclear what those issues are and what information is required to resolve them. In this paper, we have investigated PM issues faced by end-users through an empirical study of content on Stack Overflow (SO). We carried out a qualitative analysis of 1,131 questions and their accepted answer posts for three popular PMs (i.e., Maven, npm, and NuGet ) to identify issue types, underlying causes, and their resolutions. Our results confirm that end-users struggle with PM tool usage (approximately 64-72%). We observe that most issues are raised by end-users due to lack of instructions and errors messages from PM tools. In terms of issue resolution, we find that external link sharing is the most common practice to resolve PM issues. Additionally, we observe that links pointing to useful resources (i.e., official documentation websites, tutorials, etc.) are most frequently shared, indicating the potential for tool support and the ability to provide relevant information for PM end-users.

Although many software development projects have moved their developer discussion forums to generic platforms such as Stack Overflow, Eclipse has been steadfast in hosting their self-supported community forums. While recent studies show forums share similarities to generic communication channels, it is unknown how project-specific forums are utilized. In this paper, we analyze 832,058 forum threads and their linkages to four systems with 2,170 connected contributors to understand the participation, content and sentiment. Results show that Seniors are the most active participants to respond bug and non-bug-related threads in the forums (i.e., 66.1% and 45.5%), and sentiment among developers are inconsistent while knowledge sharing within Eclipse. We recommend the users to identify appropriate topics and ask in a positive procedural way when joining forums. For developers, preparing project-specific forums could be an option to bridge the communication between members. Irrespective of the popularity of Stack Overflow, we argue the benefits of using project-specific forum initiatives, such as GitHub Discussions, are needed to cultivate a community and its ecosystem.