SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

Hasan, Zobaer; Islam, Syful; Matsumoto, Kenichi; Kawai, Taro

doi:10.1038/s41598-021-96110-3

Cited by 53 publications

(46 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some of the commonly shared genes between SC2 and other viruses included E2F1, BRCA1, RAD21, CDK, DDAH2 . These genes are associated with pathways such as cell cycle process, apoptotic process, cellular nitrogen compound metabolic process, DNA repair, etc., again revealing known shared responses across viruses ( 16 , 47 ).…”

Section: Resultsmentioning

confidence: 90%

A path-based analysis of infected cell line and COVID-19 patient transcriptome reveals novel potential targets and drugs against SARS-CoV-2

Agrawal¹,

Sambaturu

Olgun³

et al. 2022

Preprint

View full text Add to dashboard Cite

Most transcriptomic studies of SARS-CoV-2 infection have focused on differentially expressedgenes, which do not necessarily reveal the genes mediating the transcriptomic changes. In contrast,exploiting curated biological network, our PathExt tool identifies central genes from thedifferentially active paths mediating global transcriptomic response. Here we apply PathExt tomultiple cell line infection models of SARS-CoV-2 and other viruses, as well as to COVID-19patient-derived PBMCs. The central genes mediating SARS-CoV-2 response in cell lines wereuniquely enriched for ATP metabolic process, G1/S transition, leukocyte activation and migration.In contrast, PBMC response reveals dysregulated cell-cycle processes. In PBMC, the mostfrequently central genes are associated with COVID-19 severity. Importantly, relative todifferential genes, PathExt-identified genes show greater concordance with several benchmarkanti-COVID-19 target gene sets. We propose six novel anti-SARS-CoV-2 targets ADCY2, ADSL,OCRL, TIAM1, PBK, and BUB1, and potential drugs targeting these genes, such as Bemcentinib,Phthalocyanine, and Conivaptan.

show abstract

Section: Resultsmentioning

confidence: 90%

A path-based analysis of infected cell line and COVID-19 patient transcriptome reveals novel potential targets and drugs against SARS-CoV-2

Agrawal¹,

Sambaturu

Olgun³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, network proximity analyses have been used for rapid identification of potential drug combinations targeting 2019-nCoV/SARS-CoV-2 46 . Therefore, network-based methodologies can be applied not only to the control of microbes in foods, industrial settings and phage therapy applications, but also to study the dynamics of the microbiome, the evolution of host and viral populations 37 , and even to fight the SARS-CoV-2 pandemic 47 . Notwithstanding these examples of implementation of biological networks comprising viruses, the systematic analysis of PCNs is still far from being widespread.…”

Section: Resultsmentioning

confidence: 99%

Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails

Molina

Menor-Flores

Fernández

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The application of bacteriophages as antibacterial agents has many benefits in the “post-antibiotic age”. To increase the number of successfully targeted bacterial strains, phage cocktails, instead of a single phage, are commonly formulated. Nevertheless, there is currently no consensus pipeline for phage cocktail development. Thus, although large cocktails increase the spectrum of activity, they could produce side effects such as the mobilization of virulence or antibiotic resistance genes. On the other hand, coinfection (simultaneous infection of one host cell by several phages) might reduce the potential for bacteria to evolve phage resistance, but some antagonistic interactions amongst phages might be detrimental for the outcome of phage cocktail application. With this in mind, we introduce here a new method, which considers the host range and each individual phage-host interaction, to design the phage mixtures that best suppress the target bacteria while minimizing the number of phages to restrict manufacturing costs. Additionally, putative phage-phage interactions in cocktails and phage-bacteria networks are compared as the understanding of the complex interactions amongst bacteriophages could be critical in the development of realistic phage therapy models in the future.

show abstract

“…Our data are in accordance with a previous report demonstrating induction of IL-17 signaling by Gal-9 treatment in vivo, in the setting of sepsis (Kadowaki et al, 2013). For MERS-CoV, SARS-CoV and now SARS-CoV-2, disease severity has been shown to positively correlate with levels of IL-17 and other T helper 17 (Th17) cell-related pro-inflammatory cytokines (Hasan et al, 2021; Mahallawi et al, 2018; Yang et al, 2020). IL-17 inhibition has been adopted as a common and successful strategy to reduce the injury associated with inflammatory autoimmune diseases (Pacha et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

Bouzidi

Gala

et al. 2022

Preprint

View full text Add to dashboard Cite

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a β-galactoside-binding lectin involved in immune regulation and viral immunopathogenesis, were reported to be elevated in the setting of severe COVID-19 disease. However, the impact of Gal-9 on SARS-CoV-2 infection and immunopathology remained to be elucidated. Here, we demonstrate that Gal-9 treatment potently enhances SARS-CoV-2 replication in human airway epithelial cells (AECs), including primary AECs in air-liquid interface (ALI) culture. Gal-9 promotes SARS-CoV-2 attachment and entry into AECs in an ACE2-dependent manner, enhancing the binding affinity of the viral spike protein to ACE2. Transcriptomic analysis revealed that Gal-9 and SARS-CoV-2 infection synergistically induced the expression of key pro-inflammatory programs in AECs including the IL-6, IL-8, IL-17, EIF2, and TNFα signaling pathways. Our findings suggest that manipulation of Gal-9 should be explored as a therapeutic strategy for SARS-CoV-2 infection.

show abstract

SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

Cited by 53 publications

References 56 publications

A path-based analysis of infected cell line and COVID-19 patient transcriptome reveals novel potential targets and drugs against SARS-CoV-2

A path-based analysis of infected cell line and COVID-19 patient transcriptome reveals novel potential targets and drugs against SARS-CoV-2

Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails

Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells

Contact Info

Product

Resources

About